3-imidazol-1-yl-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid ethyl ester

Base Information

Chemical Name:3-imidazol-1-yl-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid ethyl ester
CAS No.:1202273-70-8
Molecular Formula:C₂₆H₂₇N₃O₂
Molecular Weight:413.519
Hs Code.:

Synonyms:3-imidazol-1-yl-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid ethyl ester

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Chemical Property of 3-imidazol-1-yl-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid ethyl ester

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Technology Process of 3-imidazol-1-yl-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid ethyl ester

There total 5 articles about 3-imidazol-1-yl-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 74-96-4
ethyl bromide

: 1202273-64-0
3-imidazol-1-yl-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid methyl ester

: 1202273-70-8
3-imidazol-1-yl-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid ethyl ester

Guidance literature:: 3-imidazol-1-yl-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid methyl ester; With potassium hydroxide; In ethanol; for 72h; Reflux;

ethyl bromide; In N,N-dimethyl-formamide; at 80 ℃; for 2h;
DOI:10.1021/jm200695m

Reference yield:

: methyl 3-hydroxy-2,2-dimethyl-3-(4-nitrophenyl)propionate

: 1202273-70-8
3-imidazol-1-yl-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium on activated charcoal / ethanol / 0.5 h

2.1: pyridine; copper diacetate / dichloromethane / 72 h / 20 °C / Molecular sieve

3.1: 1,1'-carbonyldiimidazole / acetonitrile / 1 h / Reflux

4.1: potassium hydroxide / ethanol / 72 h / Reflux

4.2: pH 7

4.3: 2 h / 80 °C

With pyridine; hydrogen; copper diacetate; 1,1'-carbonyldiimidazole; potassium hydroxide; palladium on activated charcoal; In ethanol; dichloromethane; acetonitrile; 2.1: Suzuki Coupling;

Reference yield:

: 1202273-87-7
3-(4-aminophenyl)-3-hydroxy-2,2-dimethylpropionic acid methyl ester

: 1202273-70-8
3-imidazol-1-yl-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; copper diacetate / dichloromethane / 72 h / 20 °C / Molecular sieve

2.1: 1,1'-carbonyldiimidazole / acetonitrile / 1 h / Reflux

3.1: potassium hydroxide / ethanol / 72 h / Reflux

3.2: pH 7

3.3: 2 h / 80 °C

With pyridine; copper diacetate; 1,1'-carbonyldiimidazole; potassium hydroxide; In ethanol; dichloromethane; acetonitrile; 1.1: Suzuki Coupling;