4,5,6,7-Tetrahydro-azepine-1,2-dicarboxylic acid 2-methyl ester 1-phenyl ester

Base Information

Chemical Name:4,5,6,7-Tetrahydro-azepine-1,2-dicarboxylic acid 2-methyl ester 1-phenyl ester
CAS No.:213921-69-8
Molecular Formula:C₁₅H₁₇NO₄
Molecular Weight:275.304
Hs Code.:

Synonyms:4,5,6,7-Tetrahydro-azepine-1,2-dicarboxylic acid 2-methyl ester 1-phenyl ester

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Chemical Property of 4,5,6,7-Tetrahydro-azepine-1,2-dicarboxylic acid 2-methyl ester 1-phenyl ester

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Technology Process of 4,5,6,7-Tetrahydro-azepine-1,2-dicarboxylic acid 2-methyl ester 1-phenyl ester

There total 2 articles about 4,5,6,7-Tetrahydro-azepine-1,2-dicarboxylic acid 2-methyl ester 1-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 7-(Diphenoxy-phosphoryloxy)-2,3,4,5-tetrahydro-azepine-1-carboxylic acid phenyl ester

: 213921-69-8
4,5,6,7-Tetrahydro-azepine-1,2-dicarboxylic acid 2-methyl ester 1-phenyl ester

Guidance literature:: With triethylamine; palladium diacetate; triphenylphosphine; In N,N-dimethyl-formamide; at 60 ℃; under 760 Torr;
DOI:10.1039/a804198i

Reference yield:

: 24923-24-8
N-(phenyloxycarbonyl)-2-oxo-azepane

: 213921-69-8
4,5,6,7-Tetrahydro-azepine-1,2-dicarboxylic acid 2-methyl ester 1-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / KHMDS / tetrahydrofuran; toluene / 0.5 h / -78 °C

2: 82 percent / Et₃N / Pd(OAc)2, PPh₃ / dimethylformamide / 60 °C / 760 Torr

With potassium hexamethylsilazane; triethylamine; palladium diacetate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1039/a804198i

Reference yield:

: 213921-69-8
4,5,6,7-Tetrahydro-azepine-1,2-dicarboxylic acid 2-methyl ester 1-phenyl ester

: (R)-Azepane-1,2-dicarboxylic acid 2-methyl ester 1-phenyl ester

: (S)-Azepane-1,2-dicarboxylic acid 2-methyl ester 1-phenyl ester

Guidance literature:: With hydrogen; benzene; In methanol; for 24h; under 4654.3 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;
DOI:10.1039/a804198i