(R)-methyl 4-(tert-butyldiphenylsilyloxymethyl)-4,5-dihydrofuran-2-carboxylate

Base Information

Chemical Name:(R)-methyl 4-(tert-butyldiphenylsilyloxymethyl)-4,5-dihydrofuran-2-carboxylate
CAS No.:1345023-77-9
Molecular Formula:C₂₃H₂₈O₄Si
Molecular Weight:396.558
Hs Code.:

Synonyms:(R)-methyl 4-(tert-butyldiphenylsilyloxymethyl)-4,5-dihydrofuran-2-carboxylate

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Chemical Property of (R)-methyl 4-(tert-butyldiphenylsilyloxymethyl)-4,5-dihydrofuran-2-carboxylate

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Technology Process of (R)-methyl 4-(tert-butyldiphenylsilyloxymethyl)-4,5-dihydrofuran-2-carboxylate

There total 8 articles about (R)-methyl 4-(tert-butyldiphenylsilyloxymethyl)-4,5-dihydrofuran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 67-56-1
methanol

: 1345024-04-5
(R)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-4,5-dihydrofuran-2-carbonitrile

: 1345023-77-9
(R)-methyl 4-(tert-butyldiphenylsilyloxymethyl)-4,5-dihydrofuran-2-carboxylate

Guidance literature:: methanol; (R)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-4,5-dihydrofuran-2-carbonitrile; With sodium hydride; In mineral oil; at 0 - 20 ℃; Inert atmosphere;

With acetic acid; In water; mineral oil; at 20 ℃; Inert atmosphere;
DOI:10.1021/jo201716c

Reference yield: 18.0%

: 616-38-6
carbonic acid dimethyl ester

: 287933-72-6
tert-Butyl-[(R)-1-(2,3-dihydro-furan-3-yl)methoxy]-diphenyl-silane

: 1345023-77-9
(R)-methyl 4-(tert-butyldiphenylsilyloxymethyl)-4,5-dihydrofuran-2-carboxylate

Guidance literature:: tert-Butyl-[(R)-1-(2,3-dihydro-furan-3-yl)methoxy]-diphenyl-silane; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 - 0 ℃; for 1.25h; Inert atmosphere;

carbonic acid dimethyl ester; In tetrahydrofuran; pentane; at -78 ℃; for 1.25h; Inert atmosphere;
DOI:10.1021/jo201716c

Reference yield:

: 1345023-89-3
(2S,3R,4R)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-2-cyanotetrahydrofuran-3-yl acetate

: 1345023-77-9
(R)-methyl 4-(tert-butyldiphenylsilyloxymethyl)-4,5-dihydrofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 96 h / Inert atmosphere

2.1: sodium hydride / mineral oil / 0 - 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; mineral oil;
DOI:10.1021/jo201716c