3'-benzyloxy-4'-ethoxy-3,4,5-trimethoxy stilbene

Base Information

• Chemical Name: 3'-benzyloxy-4'-ethoxy-3,4,5-trimethoxy stilbene
• CAS No.: 1221156-99-5
• Molecular Formula: C₂₆H₂₈O₅
• Molecular Weight: 420.505
• Mol file: 1221156-99-5.mol

Synonyms:3'-benzyloxy-4'-ethoxy-3,4,5-trimethoxy stilbene

Chemical Property of 3'-benzyloxy-4'-ethoxy-3,4,5-trimethoxy stilbene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-benzyloxy-4'-ethoxy-3,4,5-trimethoxy stilbene

There total 6 articles about 3'-benzyloxy-4'-ethoxy-3,4,5-trimethoxy stilbene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.6%

3-(benzyloxy)-4-ethoxybenzaldehyde (26691-25-8) + triphenyl-(3,4,5-trimethoxybenzyl)phosphonium bromide (61240-20-8) → 3'-benzyloxy-4'-ethoxy-3,4,5-trimethoxy stilbene (1221156-99-5)

Guidance literature:

triphenyl-(3,4,5-trimethoxybenzyl)phosphonium bromide; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

3-(benzyloxy)-4-ethoxybenzaldehyde; In tetrahydrofuran; at 20 ℃; for 0.333333h;

Reference yield:

vanillin (121-33-5,8014-42-4) → 3'-benzyloxy-4'-ethoxy-3,4,5-trimethoxy stilbene (1221156-99-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydroxide / 18-crown-6 ether / water; isopropyl alcohol / 0.5 h

1.2: 60 °C

2.1: orthoformic acid triethyl ester / boron trifluoride diethyl etherate / 24 h / 100 °C / Inert atmosphere

3.1: lithium diphenylphosphide / tetrahydrofuran / 20 °C

3.3: pH 3 - 4

4.1: potassium carbonate / ethanol / 1 h / Reflux

5.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / 20 °C

5.2: 0.33 h / 20 °C

With potassium tert-butylate; potassium carbonate; orthoformic acid triethyl ester; lithium diphenylphosphide; sodium hydroxide; 18-crown-6 ether; boron trifluoride diethyl etherate; In tetrahydrofuran; ethanol; water; isopropyl alcohol;

Reference yield:

4-ethoxy-3-methoxybenzaldehyde (120-25-2) → 3'-benzyloxy-4'-ethoxy-3,4,5-trimethoxy stilbene (1221156-99-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: orthoformic acid triethyl ester / boron trifluoride diethyl etherate / 24 h / 100 °C / Inert atmosphere

2.1: lithium diphenylphosphide / tetrahydrofuran / 20 °C

2.3: pH 3 - 4

3.1: potassium carbonate / ethanol / 1 h / Reflux

4.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / 20 °C

4.2: 0.33 h / 20 °C

With potassium tert-butylate; potassium carbonate; orthoformic acid triethyl ester; lithium diphenylphosphide; boron trifluoride diethyl etherate; In tetrahydrofuran; ethanol;

upstream raw materials:

vanillin

3-(benzyloxy)-4-ethoxybenzaldehyde

triphenyl-(3,4,5-trimethoxybenzyl)phosphonium bromide

4-ethoxy-3-methoxybenzaldehyde

Downstream raw materials:

3'-hydroxyl-4'-ethoxy-3,4,5-trimethoxy diphenylethane

C₃₃H₃₇O₈P

Refernces

• 1、 -. "Preparation and application for 5-fluorouracil substituted carboxylic acid derivative". Paragraph 0057; 0058; 0059; 0060. . Retrieved 2018/03/26.
• 2、 -. "ETHOXY DIPHENYL ETHANE DERIVATES, PREPARATION PROCESSES AND USES THEREOF". . . Retrieved 2011/08/08.