(S)-1-[(2R,2aR,5aS,7R,8bR)-4,4-Di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethane-1,2-diol

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Chemical Name:(S)-1-[(2R,2aR,5aS,7R,8bR)-4,4-Di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethane-1,2-diol
CAS No.:225113-12-2
Molecular Formula:C₂₈H₄₅NO₇Si
Molecular Weight:535.753
Hs Code.:

Synonyms:(S)-1-[(2R,2aR,5aS,7R,8bR)-4,4-Di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethane-1,2-diol

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Chemical Property of (S)-1-[(2R,2aR,5aS,7R,8bR)-4,4-Di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethane-1,2-diol

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Technology Process of (S)-1-[(2R,2aR,5aS,7R,8bR)-4,4-Di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethane-1,2-diol

There total 5 articles about (S)-1-[(2R,2aR,5aS,7R,8bR)-4,4-Di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 225113-10-0
(2R,2aR,5aS,7R,8bR)-4,4-Di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-2-vinyl-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylene

: 225113-11-1
(R)-1-[(2R,2aR,5aS,7R,8bR)-4,4-Di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethane-1,2-diol

: 225113-12-2
(S)-1-[(2R,2aR,5aS,7R,8bR)-4,4-Di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethane-1,2-diol

Guidance literature:: With (DHQD)2AQN; potassium dioxotetrahydroxoosmate(VI); sodium hydrogencarbonate; potassium carbonate; potassium hexacyanoferrate(III); In tert-butyl alcohol; Yields of byproduct given; Ambient temperature;
DOI:10.1021/ja9829970

Reference yield:

: 134436-16-1
di-t-butylchlorosilane monotriflate

: 225113-12-2
(S)-1-[(2R,2aR,5aS,7R,8bR)-4,4-Di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethane-1,2-diol

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / 1.) THF, -23 deg C, 2.) THF, from -78 deg C to -25 deg C

2: 85 percent Spectr_. / CHCl₃; acetonitrile / 8 h / Ambient temperature

3: methylaluminum bis(2,6-diphenylphenoxide) / CH₂Cl₂ / 2 h / -50 °C

4: NaHCO₃ / benzene / 4 h / Heating

5: 86 percent / K₂OsO₂(OH)4, aq. K₂CO₃, NaHCO₃, K₃Fe(CN)6, (DHQD)2-AQN ligand / 2-methyl-propan-2-ol / Ambient temperature

With n-butyllithium; (DHQD)2AQN; potassium dioxotetrahydroxoosmate(VI); sodium hydrogencarbonate; potassium carbonate; methylaluminium bis(2,6-diphenylphenoxide); potassium hexacyanoferrate(III); In dichloromethane; chloroform; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/ja9829970

Reference yield:

: 225113-08-6
[((Z)-Buta-1,3-dienyl)oxy]-di-tert-butyl-chloro-silane

: 225113-12-2
(S)-1-[(2R,2aR,5aS,7R,8bR)-4,4-Di-tert-butyl-7-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,3,5,8-tetraoxa-8a-aza-4-sila-acenaphthylen-2-yl]-ethane-1,2-diol

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent Spectr_. / CHCl₃; acetonitrile / 8 h / Ambient temperature

2: methylaluminum bis(2,6-diphenylphenoxide) / CH₂Cl₂ / 2 h / -50 °C

3: NaHCO₃ / benzene / 4 h / Heating

4: 86 percent / K₂OsO₂(OH)4, aq. K₂CO₃, NaHCO₃, K₃Fe(CN)6, (DHQD)2-AQN ligand / 2-methyl-propan-2-ol / Ambient temperature

With (DHQD)2AQN; potassium dioxotetrahydroxoosmate(VI); sodium hydrogencarbonate; potassium carbonate; methylaluminium bis(2,6-diphenylphenoxide); potassium hexacyanoferrate(III); In dichloromethane; chloroform; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/ja9829970