5r-chloromethyl-2-fluoro-5-methyl-[1,3,2]dioxaphosphinane 2t-oxide

Base Information

• Chemical Name: 5r-chloromethyl-2-fluoro-5-methyl-[1,3,2]dioxaphosphinane 2t-oxide
• CAS No.: 74737-10-3
• Molecular Formula: C₅H₉ClFO₃P
• Molecular Weight: 202.55
• Mol file: 74737-10-3.mol

Synonyms:5r-chloromethyl-2-fluoro-5-methyl-[1,3,2]dioxaphosphinane 2t-oxide

Chemical Property of 5r-chloromethyl-2-fluoro-5-methyl-[1,3,2]dioxaphosphinane 2t-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5r-chloromethyl-2-fluoro-5-methyl-[1,3,2]dioxaphosphinane 2t-oxide

There total 2 articles about 5r-chloromethyl-2-fluoro-5-methyl-[1,3,2]dioxaphosphinane 2t-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane (36912-34-2) → 5r-chloromethyl-2-fluoro-5-methyl-[1,3,2]dioxaphosphinane 2t-oxide (74737-10-3) + 5r-chloromethyl-2-fluoro-5-methyl-[1,3,2]dioxaphosphinane 2c-oxide (74737-11-4) + cis-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane (36912-33-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1021/ja00316a041

Reference yield:

p-cresol (106-44-5) + trans-2-chloro-5-methyl-1,3,2-dioxaphosphorinane-r-5-methyl chloride 2-oxide (28097-07-6) → 5r-chloromethyl-2-fluoro-5-methyl-[1,3,2]dioxaphosphinane 2t-oxide (74737-10-3) + 5r-chloromethyl-2-fluoro-5-methyl-[1,3,2]dioxaphosphinane 2c-oxide (74737-11-4) + cis-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane (36912-33-1) + trans-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane (36912-34-2)

Guidance literature:

With cesium fluoride; In isopropyl alcohol; Yield given;

DOI:10.1021/ja00316a041

Reference yield:

5r-chloromethyl-2-fluoro-5-methyl-[1,3,2]dioxaphosphinane 2t-oxide (74737-10-3) → cis-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane (36912-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1: CsF / tetrahydrofuran

2: tetrabutylammonium fluoride / tetrahydrofuran

With tetrabutyl ammonium fluoride; cesium fluoride; In tetrahydrofuran;

DOI:10.1021/ja00316a041

upstream raw materials:

p-cresol

trans-2-chloro-5-methyl-1,3,2-dioxaphosphorinane-r-5-methyl chloride 2-oxide

trans-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane

Downstream raw materials:

cis-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane

trans-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane

trans-2-<(p-methoxyphenyl)oxy>-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane

5-Chloromethyl-5-methyl-2-phenoxy-[1,3,2]dioxaphosphinane 2-oxide