trans-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane

Base Information

• Chemical Name: trans-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane
• CAS No.: 36912-34-2
• Molecular Formula: C₁₂H₁₆ClO₄P
• Molecular Weight: 290.683
• Mol file: 36912-34-2.mol

Synonyms:trans-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane

Chemical Property of trans-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane

There total 7 articles about trans-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-cresol (106-44-5) + trans-2-chloro-5-methyl-1,3,2-dioxaphosphorinane-r-5-methyl chloride 2-oxide (28097-07-6) → cis-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane (36912-33-1) + trans-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane (36912-34-2)

Guidance literature:

With triethylamine; In dichloromethane; for 2h; Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(01)88163-1

Reference yield:

trans-2-chloro-5-methyl-1,3,2-dioxaphosphorinane-r-5-methyl chloride 2-oxide (28097-07-6) → trans-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane (36912-34-2)

Guidance literature:

Multi-step reaction with 2 steps

1: CsF

2: CsF / tetrahydrofuran

With cesium fluoride; In tetrahydrofuran;

DOI:10.1021/ja00316a041

Reference yield:

p-cresol (106-44-5) + 5r-chloromethyl-2-fluoro-5-methyl-[1,3,2]dioxaphosphinane 2t-oxide (74737-10-3) → cis-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane (36912-33-1) + trans-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane (36912-34-2)

Guidance literature:

With cesium fluoride; In tetrahydrofuran;

DOI:10.1021/ja00316a041

upstream raw materials:

p-cresol

5r-chloromethyl-2-fluoro-5-methyl-[1,3,2]dioxaphosphinane 2t-oxide

trans-2-chloro-5-methyl-1,3,2-dioxaphosphorinane-r-5-methyl chloride 2-oxide

sodium 4-methylphenoxide

Downstream raw materials:

5r-chloromethyl-2-fluoro-5-methyl-[1,3,2]dioxaphosphinane 2t-oxide

5r-chloromethyl-2-fluoro-5-methyl-[1,3,2]dioxaphosphinane 2c-oxide

cis-2-(p-methylphenoxy)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane

cis-2-<(p-methoxyphenyl)oxy>-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane