benzyl {(7S,8R)-7-[((3-((4-fluorophenyl)propyl)(propyl)amino)methyl)]-1,4-dioxa-spiro[4.5]dec-8-yl}-carbamate

Base Information

Chemical Name:benzyl {(7S,8R)-7-[((3-((4-fluorophenyl)propyl)(propyl)amino)methyl)]-1,4-dioxa-spiro[4.5]dec-8-yl}-carbamate
CAS No.:852661-42-8
Molecular Formula:C₂₉H₃₉FN₂O₄
Molecular Weight:498.638
Hs Code.:

Synonyms:benzyl {(7S,8R)-7-[((3-((4-fluorophenyl)propyl)(propyl)amino)methyl)]-1,4-dioxa-spiro[4.5]dec-8-yl}-carbamate

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Chemical Property of benzyl {(7S,8R)-7-[((3-((4-fluorophenyl)propyl)(propyl)amino)methyl)]-1,4-dioxa-spiro[4.5]dec-8-yl}-carbamate

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Technology Process of benzyl {(7S,8R)-7-[((3-((4-fluorophenyl)propyl)(propyl)amino)methyl)]-1,4-dioxa-spiro[4.5]dec-8-yl}-carbamate

There total 13 articles about benzyl {(7S,8R)-7-[((3-((4-fluorophenyl)propyl)(propyl)amino)methyl)]-1,4-dioxa-spiro[4.5]dec-8-yl}-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 813445-24-8
((7R,8R)-7-Formyl-1,4-dioxa-spiro[4.5]dec-8-yl)-carbamic acid benzyl ester

: 852660-77-6
3-(4-fluorophenyl)-N-propylpropan-1-amine

: 852661-42-8
benzyl {(7S,8R)-7-[((3-((4-fluorophenyl)propyl)(propyl)amino)methyl)]-1,4-dioxa-spiro[4.5]dec-8-yl}-carbamate

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 136265-10-6,352-03-4,24393-50-8
ethyl 4-fluorocinnamate

: 852661-42-8
benzyl {(7S,8R)-7-[((3-((4-fluorophenyl)propyl)(propyl)amino)methyl)]-1,4-dioxa-spiro[4.5]dec-8-yl}-carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 2585.81 Torr

2.1: sodium hydroxide; water / methanol / Heating / reflux

2.2: pH 1

3.1: thionyl chloride / dichloromethane / 24 h / 25 °C

4.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Heating / reflux

6.1: sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; water; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 852661-42-8
benzyl {(7S,8R)-7-[((3-((4-fluorophenyl)propyl)(propyl)amino)methyl)]-1,4-dioxa-spiro[4.5]dec-8-yl}-carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / Heating / reflux

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2585.81 Torr

3.1: sodium hydroxide; water / methanol / Heating / reflux

3.2: pH 1

4.1: thionyl chloride / dichloromethane / 24 h / 25 °C

5.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Heating / reflux

7.1: sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; water; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;