(5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)boronic acid

Base Information

Chemical Name:(5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)boronic acid
CAS No.:1263407-24-4
Molecular Formula:C₁₈H₁₉BFNO₃S
Molecular Weight:359.229
Hs Code.:

Synonyms:(5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)boronic acid

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Chemical Property of (5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)boronic acid

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Technology Process of (5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)boronic acid

There total 4 articles about (5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 1263407-33-5
C₇H₁₀BNO₂S*C₇H₈O₃S

: 1263407-24-4
(5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)boronic acid

Guidance literature:: C₇H₁₀BNO₂S*C₇H₈O₃S; With triethylamine; In ethanol; at 50 ℃; Inert atmosphere;

2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; In ethanol; at 50 ℃; for 8h;
DOI:10.3184/174751913X13687269227225

Reference yield:

: 28783-41-7
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

: 1263407-24-4
(5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)boronic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / dichloromethane / 0.25 h / 20 °C

1.2: 8 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -10 - 0 °C / Inert atmosphere

2.2: 1.5 h / -10 °C

3.1: tetrahydrofuran / 0 - 20 °C

4.1: triethylamine / ethanol / 50 °C / Inert atmosphere

4.2: 8 h / 50 °C

With n-butyllithium; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane;
DOI:10.3184/174751913X13687269227225

Reference yield:

: 109904-25-8
N-trityl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

: 1263407-24-4
(5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)boronic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -10 - 0 °C / Inert atmosphere

1.2: 1.5 h / -10 °C

2.1: tetrahydrofuran / 0 - 20 °C

3.1: triethylamine / ethanol / 50 °C / Inert atmosphere

3.2: 8 h / 50 °C

With n-butyllithium; triethylamine; In tetrahydrofuran; ethanol; hexane;
DOI:10.3184/174751913X13687269227225