N-(1-{4-[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]benzyl}piperidin-4-yl)-2-methoxyacetamide

Base Information

Chemical Name:N-(1-{4-[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]benzyl}piperidin-4-yl)-2-methoxyacetamide
CAS No.:1400796-78-2
Molecular Formula:C₂₃H₂₈N₂O₄
Molecular Weight:396.486
Hs Code.:

Synonyms:N-(1-{4-[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]benzyl}piperidin-4-yl)-2-methoxyacetamide

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Chemical Property of N-(1-{4-[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]benzyl}piperidin-4-yl)-2-methoxyacetamide

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Technology Process of N-(1-{4-[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]benzyl}piperidin-4-yl)-2-methoxyacetamide

There total 16 articles about N-(1-{4-[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]benzyl}piperidin-4-yl)-2-methoxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400796-75-9
1-[(S)-4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzyl]-piperidin-4-ylamine hydrochloride

: 625-45-6
2-methoxyacetic acid

: 1400796-78-2
N-(1-{4-[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]benzyl}piperidin-4-yl)-2-methoxyacetamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; for 2h;

Reference yield:

: 20099-89-2
4-Cyanophenacyl bromide

: 1400796-78-2
N-(1-{4-[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]benzyl}piperidin-4-yl)-2-methoxyacetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetonitrile / 0.75 h / 20 °C / Inert atmosphere

1.2: 0.83 h / 20 - 25 °C / Inert atmosphere

2.1: triethylamine; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine / acetonitrile / 1 h / 20 °C

2.2: 0.5 h / 5 - 15 °C

3.1: copper(l) iodide; 1,10-Phenanthroline / 1,4-dioxane / Inert atmosphere; Reflux

4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2.5 h / 0 - 20 °C

5.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 18 h

6.1: hydrogenchloride / methanol; 1,4-dioxane / 18 h

7.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 2 h

With hydrogenchloride; copper(l) iodide; 1,10-Phenanthroline; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 533-58-4
2-Iodophenol

: 1400796-78-2
N-(1-{4-[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]benzyl}piperidin-4-yl)-2-methoxyacetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetonitrile / 0.75 h / 20 °C / Inert atmosphere

1.2: 0.83 h / 20 - 25 °C / Inert atmosphere

2.1: triethylamine; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine / acetonitrile / 1 h / 20 °C

2.2: 0.5 h / 5 - 15 °C

3.1: copper(l) iodide; 1,10-Phenanthroline / 1,4-dioxane / Inert atmosphere; Reflux

4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2.5 h / 0 - 20 °C

5.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 18 h

6.1: hydrogenchloride / methanol; 1,4-dioxane / 18 h

7.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 2 h

With hydrogenchloride; copper(l) iodide; 1,10-Phenanthroline; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; acetonitrile;