2-(4-((3-amino-6-iodoquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile

Base Information

Chemical Name:2-(4-((3-amino-6-iodoquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile
CAS No.:1628077-36-0
Molecular Formula:C₁₉H₁₇IN₄
Molecular Weight:428.275
Hs Code.:

Synonyms:2-(4-((3-amino-6-iodoquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile

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Chemical Property of 2-(4-((3-amino-6-iodoquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile

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Technology Process of 2-(4-((3-amino-6-iodoquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile

There total 6 articles about 2-(4-((3-amino-6-iodoquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1628078-09-0
2-(4-((6-iodo-3-nitroquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile

: 1628077-36-0
2-(4-((3-amino-6-iodoquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile

Guidance literature:: With iron; ammonium chloride; In ethanol; water; for 2h; Reflux; Heating;
DOI:10.1021/jm500361r

Reference yield:

: 1203578-70-4,1345447-23-5
6-iodo-3-nitroquinolin-4-ol

: 1628077-36-0
2-(4-((3-amino-6-iodoquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 2 h / 20 - 120 °C

2: acetic acid / 3 h / 20 °C / Inert atmosphere

3: iron; ammonium chloride / ethanol; water / 2 h / Reflux; Heating

With iron; ammonium chloride; acetic acid; trichlorophosphate; In ethanol; water;
DOI:10.1021/jm500361r

Reference yield:

: 1345447-21-3
5-iodo-2-((2-nitrovinyl)amino)benzoic acid

: 1628077-36-0
2-(4-((3-amino-6-iodoquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate; acetic anhydride / 1.5 h / 120 °C

2: trichlorophosphate / 2 h / 20 - 120 °C

3: acetic acid / 3 h / 20 °C / Inert atmosphere

4: iron; ammonium chloride / ethanol; water / 2 h / Reflux; Heating

With potassium acetate; acetic anhydride; iron; ammonium chloride; acetic acid; trichlorophosphate; In ethanol; water;
DOI:10.1021/jm500361r