2-(4-(3,8-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Base Information

Chemical Name:2-(4-(3,8-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile
CAS No.:1610680-68-6
Molecular Formula:C₂₂H₂₀N₄O
Molecular Weight:356.427
Hs Code.:

Synonyms:2-(4-(3,8-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

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Chemical Property of 2-(4-(3,8-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

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Technology Process of 2-(4-(3,8-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

There total 9 articles about 2-(4-(3,8-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1610680-63-1
2-(4-(8-iodo-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

: 5158-46-3
methylzinc chloride

: 1610680-68-6
2-(4-(3,8-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 75 ℃; for 1h; Microwave irradiation; Inert atmosphere; Sealed tube;
DOI:10.1021/jm500361r

Reference yield:

: 1203578-70-4,1345447-23-5
6-iodo-3-nitroquinolin-4-ol

: 1610680-68-6
2-(4-(3,8-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 6 steps

1: trichlorophosphate / 2 h / 20 - 120 °C

2: acetic acid / 3 h / 20 °C / Inert atmosphere

3: iron; ammonium chloride / ethanol; water / 2 h / Reflux; Heating

4: triethylamine / dichloromethane / 2 h / 0 - 20 °C

5: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 24 h / 20 °C / Sealed tube

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1 h / 75 °C / Microwave irradiation; Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; iron; ammonium chloride; acetic acid; triethylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; 6: |Negishi Coupling;
DOI:10.1021/jm500361r

Reference yield:

: 1345447-21-3
5-iodo-2-((2-nitrovinyl)amino)benzoic acid

: 1610680-68-6
2-(4-(3,8-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 7 steps

1: potassium acetate; acetic anhydride / 1.5 h / 120 °C

2: trichlorophosphate / 2 h / 20 - 120 °C

3: acetic acid / 3 h / 20 °C / Inert atmosphere

4: iron; ammonium chloride / ethanol; water / 2 h / Reflux; Heating

5: triethylamine / dichloromethane / 2 h / 0 - 20 °C

6: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 24 h / 20 °C / Sealed tube

7: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1 h / 75 °C / Microwave irradiation; Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; potassium acetate; acetic anhydride; iron; ammonium chloride; acetic acid; triethylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; 7: |Negishi Coupling;
DOI:10.1021/jm500361r