N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-3-fluorobenzoyl)-2,2-dimethylpiperazin-1-yl)methyl)benzamide

Base Information

Chemical Name:N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-3-fluorobenzoyl)-2,2-dimethylpiperazin-1-yl)methyl)benzamide
CAS No.:1124215-13-9
Molecular Formula:C₃₀H₄₀FN₅O₃
Molecular Weight:537.678
Hs Code.:

Synonyms:N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-3-fluorobenzoyl)-2,2-dimethylpiperazin-1-yl)methyl)benzamide

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Chemical Property of N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-3-fluorobenzoyl)-2,2-dimethylpiperazin-1-yl)methyl)benzamide

Chemical Property:

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Technology Process of N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-3-fluorobenzoyl)-2,2-dimethylpiperazin-1-yl)methyl)benzamide

There total 6 articles about N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-3-fluorobenzoyl)-2,2-dimethylpiperazin-1-yl)methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1124215-23-1
3-((4-(4-amino-3-fluorobenzoyl)-2,2-dimethylpiperazin-1-yl)methyl)-N-tert-butyl-benzamide

: 2516-34-9
cyclobutylamine

: 7693-46-1
4-Nitrophenyl chloroformate

: 1124215-13-9
N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-3-fluorobenzoyl)-2,2-dimethylpiperazin-1-yl)methyl)benzamide

Guidance literature:: 3-((4-(4-amino-3-fluorobenzoyl)-2,2-dimethylpiperazin-1-yl)methyl)-N-tert-butyl-benzamide; 4-Nitrophenyl chloroformate; In dichloromethane; for 2h;

cyclobutylamine; In dichloromethane; for 16h;

Reference yield:

: 1124215-20-8
tert-butyl 4-(4-amino-3-fluorobenzoyl)-2,2-dimethylpiperazine-1-carboxylate

: 1124215-13-9
N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-3-fluorobenzoyl)-2,2-dimethylpiperazin-1-yl)methyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h

2.1: triethylamine / sodium iodide / dichloromethane; acetonitrile / 3 h / Reflux

3.1: dichloromethane / 2 h

3.2: 16 h

With triethylamine; trifluoroacetic acid; sodium iodide; In dichloromethane; acetonitrile;

Reference yield:

: 63024-77-1
3-(Chloromethyl)benzoyl chloride

: 1124215-13-9
N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-3-fluorobenzoyl)-2,2-dimethylpiperazin-1-yl)methyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -30 - 20 °C

2.1: triethylamine / sodium iodide / dichloromethane; acetonitrile / 3 h / Reflux

3.1: dichloromethane / 2 h

3.2: 16 h

With triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; In dichloromethane; acetonitrile;