(R)-2-(Benzhydrylidene-amino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid tert-butyl ester

Base Information

• Chemical Name: (R)-2-(Benzhydrylidene-amino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid tert-butyl ester
• CAS No.: 178217-05-5
• Molecular Formula: C₂₆H₂₅FN₂O₄
• Molecular Weight: 448.494
• Mol file: 178217-05-5.mol

Synonyms:(R)-2-(Benzhydrylidene-amino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid tert-butyl ester

Chemical Property of (R)-2-(Benzhydrylidene-amino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(Benzhydrylidene-amino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid tert-butyl ester

There total 4 articles about (R)-2-(Benzhydrylidene-amino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-(diphenylmethylene)glycine tert-butyl ester (81477-94-3) + 4-(bromomethyl)-1-fluoro-2-nitrobenzene (15017-52-4) → (R)-2-(Benzhydrylidene-amino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid tert-butyl ester (178217-05-5)

Guidance literature:

With sodium hydroxide; N-benzylcinchoninium bromide;

DOI:10.1016/0040-4039(96)00459-5

Reference yield:

4-fluoro-3-nitrobenzaldehyde (42564-51-2) → (R)-2-(Benzhydrylidene-amino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid tert-butyl ester (178217-05-5)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₄ / methanol

2: PBr₃ / diethyl ether

3: 80 percent / N-benzylcinchoninium bromide, 50 percent aq. NaOH

With sodium hydroxide; sodium tetrahydroborate; N-benzylcinchoninium bromide; phosphorus tribromide; In methanol; diethyl ether;

DOI:10.1016/0040-4039(96)00459-5

Reference yield:

(4-fluoro-3-nitrophenyl)methanol (20274-69-5) → (R)-2-(Benzhydrylidene-amino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid tert-butyl ester (178217-05-5)

Guidance literature:

Multi-step reaction with 2 steps

1: PBr₃ / diethyl ether

2: 80 percent / N-benzylcinchoninium bromide, 50 percent aq. NaOH

With sodium hydroxide; N-benzylcinchoninium bromide; phosphorus tribromide; In diethyl ether;

DOI:10.1016/0040-4039(96)00459-5

upstream raw materials:

N-(diphenylmethylene)glycine tert-butyl ester

4-(bromomethyl)-1-fluoro-2-nitrobenzene

(4-fluoro-3-nitrophenyl)methanol

4-fluoro-3-nitrobenzaldehyde

Downstream raw materials:

(R)-[(S)-2-[(R)-2-tert-Butoxycarbonylamino-3-(4-fluoro-3-nitro-phenyl)-propionylamino]-2-(3,5-dimethoxy-phenyl)-acetylamino]-(3-hydroxy-4-methoxy-phenyl)-acetic acid methyl ester

(R)-N-(tert-butoxycarbonyl)-4-fluoro-3-nitrophenylalanine methyl ester

(R)-N-(tert-butoxycarbonyl)-4-fluoro-3-nitrophenylalanine