Technology Process of 7-(benzyloxy)-4,5-difluoro-3,3-dimethylindoline
There total 4 articles about 7-(benzyloxy)-4,5-difluoro-3,3-dimethylindoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2-(benzyloxy)-4,5-difluorophenyl)hydrazine; isobutyraldehyde;
With
sulfuric acid;
In
ethanol;
at 0 - 20 ℃;
for 18h;
Inert atmosphere;
With
methanol; sodium tetrahydroborate;
at -10 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: ferric nitrate / ethanol / 16 h / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C
2.2: 4 h / 20 °C
3.1: sodium nitrite; hydrogenchloride / water / 2 h / 0 °C
3.2: 0.5 h
4.1: sulfuric acid / ethanol / 18 h / 0 - 20 °C / Inert atmosphere
4.2: -10 °C
With
hydrogenchloride; sulfuric acid; potassium carbonate; ferric nitrate; sodium nitrite;
In
ethanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C
1.2: 4 h / 20 °C
2.1: sodium nitrite; hydrogenchloride / water / 2 h / 0 °C
2.2: 0.5 h
3.1: sulfuric acid / ethanol / 18 h / 0 - 20 °C / Inert atmosphere
3.2: -10 °C
With
hydrogenchloride; sulfuric acid; potassium carbonate; sodium nitrite;
In
ethanol; water; N,N-dimethyl-formamide;
