4-(4-(biphenyl-4-ylmethyl)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide

Base Information

Chemical Name:4-(4-(biphenyl-4-ylmethyl)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide
CAS No.:1073502-80-3
Molecular Formula:C₃₂H₃₉ClN₂O₂
Molecular Weight:519.127
Hs Code.:

Synonyms:4-(4-(biphenyl-4-ylmethyl)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide

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Chemical Property of 4-(4-(biphenyl-4-ylmethyl)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide

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Technology Process of 4-(4-(biphenyl-4-ylmethyl)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide

There total 4 articles about 4-(4-(biphenyl-4-ylmethyl)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1073502-79-0
4-(4-(biphenyl-4-ylmethylene)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide

: 1073502-80-3
4-(4-(biphenyl-4-ylmethyl)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; at 20 ℃; for 2.5h;

Reference yield:

: 30818-70-3
diethyl (4-biphenylmethyl)phosphonate

: 1073502-80-3
4-(4-(biphenyl-4-ylmethyl)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / 15-crown-5 / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 4.17 h / 0 - 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 20 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2.5 h / 20 °C

With hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 15-crown-5; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; mineral oil;

Reference yield:

: 2567-29-5
p-phenylbenzyl bromide

: 1073502-80-3
4-(4-(biphenyl-4-ylmethyl)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 26 h / 100 - 150 °C / Inert atmosphere

2.1: sodium hydride / 15-crown-5 / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 4.17 h / 0 - 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 20 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2.5 h / 20 °C

With hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 15-crown-5; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; mineral oil;