4-(4-(biphenyl-4-ylmethylene)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide

Base Information

Chemical Name:4-(4-(biphenyl-4-ylmethylene)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide
CAS No.:1073502-79-0
Molecular Formula:C₃₂H₃₇ClN₂O₂
Molecular Weight:517.111
Hs Code.:

Synonyms:4-(4-(biphenyl-4-ylmethylene)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide

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Chemical Property of 4-(4-(biphenyl-4-ylmethylene)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide

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Technology Process of 4-(4-(biphenyl-4-ylmethylene)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide

There total 3 articles about 4-(4-(biphenyl-4-ylmethylene)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1073502-78-9
4-(4-(biphenyl-4-ylmethylene)cyclohexyloxy)-3-chlorobenzoic acid

: 100-36-7
N,N-diethylethylenediamine

: 1073502-79-0
4-(4-(biphenyl-4-ylmethylene)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 30818-70-3
diethyl (4-biphenylmethyl)phosphonate

: 1073502-79-0
4-(4-(biphenyl-4-ylmethylene)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / 15-crown-5 / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 4.17 h / 0 - 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 20 °C / Inert atmosphere

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 15-crown-5; In tetrahydrofuran; dichloromethane; mineral oil;

Reference yield:

: 2567-29-5
p-phenylbenzyl bromide

: 1073502-79-0
4-(4-(biphenyl-4-ylmethylene)cyclohexyloxy)-3-chloro-N-(2-diethylamino)ethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 26 h / 100 - 150 °C / Inert atmosphere

2.1: sodium hydride / 15-crown-5 / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 4.17 h / 0 - 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 20 °C / Inert atmosphere

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 15-crown-5; In tetrahydrofuran; dichloromethane; mineral oil;