2-Hydroxy-1-(4-methoxyphenyl)-2,2-diphenylethanone

Base Information

• Chemical Name: 2-Hydroxy-1-(4-methoxyphenyl)-2,2-diphenylethanone
• CAS No.: 4338-69-6
• Molecular Formula: C₂₁H₁₈O₃
• Molecular Weight: 318.372
• Mol file: 4338-69-6.mol

Synonyms:2-Hydroxy-1-(4-methoxyphenyl)-2,2-diphenylethanone

Chemical Property of 2-Hydroxy-1-(4-methoxyphenyl)-2,2-diphenylethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Hydroxy-1-(4-methoxyphenyl)-2,2-diphenylethanone

There total 5 articles about 2-Hydroxy-1-(4-methoxyphenyl)-2,2-diphenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

benzophenone (119-61-9) + 4-methoxybenzonitrile (874-90-8) → 2-Hydroxy-1-(4-methoxyphenyl)-2,2-diphenylethanone (4338-69-6)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; for 6h; Heating;

DOI:10.1055/s-2000-6220

Reference yield:

4-methoxybenzil (22711-21-3) + trimethyl(phenyl)stannane (934-56-5) → 2-Hydroxy-1-(4-methoxyphenyl)-2,2-diphenylethanone (4338-69-6) + 2-hydroxy-2-(4-methoxyphenyl)-1,2-diphenylethanone (367935-16-8)

Guidance literature:

With bis(acetonitrile)(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; In tetrahydrofuran; at 60 ℃; for 20h; Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(03)00586-6

Reference yield:

C24H26O3Si → 2-Hydroxy-1-(4-methoxyphenyl)-2,2-diphenylethanone (4338-69-6)

Guidance literature:

C₂₄H₂₆O₃Si; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.166667h; Inert atmosphere;

With water; In tetrahydrofuran; diethyl ether; Inert atmosphere;

DOI:10.1021/jo100312w

upstream raw materials:

1-(4-methoxyphenyl)-2,2-diphenylethanone

benzophenone

4-methoxybenzonitrile

4-methoxybenzil

Downstream raw materials:

1-(4-methoxyphenyl)-2,2-diphenylethanone