22711-21-3

Basic information

• Product Name: P-METHOXYBENZIL
• Synonyms: 1-(4-METHOXY-PHENYL)-2-PHENYL-ETHANE-1,2-DIONE;4-METHOXYBENZIL;P-METHOXYBENZIL;(4-methoxyphenyl)phenyl-ethanedion;1-(4-Methoxyphenyl)-2-phenyl-1,2-ethanedione;1-(4-Methoxyphenyl)-2-phenyl-ethan-1,2-dion;1-(4-Methoxyphenyl)-2-phenyl-ethan-1,2-dione;1-(4-methoxyphenyl)-2-phenylethanedione
• CAS NO: 22711-21-3
• Molecular Formula: C₁₅H₁₂O₃
• Molecular Weight: 240.25
• Product Categories: Aromatic Ketones (substituted)
• Mol File: 22711-21-3.mol
• Article Data: 96

Chemical Properties

• Boiling Point: 398.7°Cat760mmHg
• Flash Point: 178.1°C
• Appearance: /
• Density: 1.175g/cm³
• Vapor Pressure: 1.45E-06mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: P-METHOXYBENZIL(CAS DataBase Reference)
• NIST Chemistry Reference: P-METHOXYBENZIL(22711-21-3)
• EPA Substance Registry System: P-METHOXYBENZIL(22711-21-3)

Safety Data

• Hazardous Substances Data: 22711-21-3(Hazardous Substances Data)

Usage

General Description

P-METHOXYBENZIL, also known as 1-(4-methoxyphenyl)ethan-1-one, is a chemical compound that belongs to the class of aromatic ketones. It is commonly used as a building block in organic synthesis and serves as a versatile intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals. P-METHOXYBENZIL has a molecular formula of C9H10O2 and a molecular weight of 150.18 g/mol. It is a white crystalline solid that is insoluble in water but soluble in most organic solvents. The compound exhibits a melting point of 79-82°C and a boiling point of 274-276°C. Due to its versatile reactivity and structural properties, P-METHOXYBENZIL is widely utilized in the pharmaceutical industry for the synthesis of various drug molecules.

InChI:InChI=1/C15H12O3/c1-18-13-9-7-12(8-10-13)15(17)14(16)11-5-3-2-4-6-11/h2-10H,1H3

Upstream product

• 4254-17-5 4-methoxybenzoin 
• 100-52-7 benzaldehyde 
• 123-11-5 4-methoxy-benzaldehyde 
• 1889-77-6 2-bromo-1-(4-methoxy-phenyl)-2-phenyl-ethanone 
• 1694-22-0 (E)-2-(4-methoxyphenyl)-3-phenylacrylic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 591-51-5 phenyllithium 
• 156909-31-8 1,4-Didecylpiperazine-2,3-dione 
• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 
• 536-74-3 phenylacetylene 
• 100-07-2 4-methoxy-benzoyl chloride 
• 6327-79-3 1-(4-methoxyphenyl)-3-phenylpropane-1,3-dione 
• 1657-53-0 cis-4-methoxystilbene 

Downstream Products

• 65648-91-1 3-(4-methoxy-phenyl)-2,4,5-triphenyl-cyclopentadienone 
• 108791-37-3 2,2-dichloro-1-(4-methoxyphenyl)-2-phenylethanone 
• 93-89-0 benzoic acid ethyl ester 
• 94-30-4 ethyl 4-methoxybenzoate 
• 100-09-4 4-methoxybenzoic acid 
• 65-85-0 benzoic acid 
• 4338-69-6 2-Hydroxy-1-(4-methoxyphenyl)-2,2-diphenylethanone 
• 367935-16-8 2-hydroxy-2-(4-methoxyphenyl)-1,2-diphenylethanone 
• 869565-38-8 2,5-dicarbethoxy-3-(4'-methoxyphenyl)-4-phenylcyclopenta-2,4-dienone 
• 1028432-46-3 2-(4-methoxyphenyl)-6,7-dimethyl-3-phenylquinoxaline 
• 10166-78-6 2-(4-methoxyphenyl)-3-phenylquinoxaline 
• 776-75-0 N-benzoylpiperidine 
• 57700-94-4 N-(p-methoxybenzoyl)piperidine 

Relevant articles and documents

Structural Effects in Photoepoxidation Sensitized by α-Diketones

A series of α-diketones and benzils were examined for their effectiveness as sensitizers in the photoepoxidation reaction.The reduction potentials of these α-diketones were also determined at a hanging-mercury-drop electrode.The reduction potentials of the p,p'-disubstituted-benzils were successfully correlated to the sum of the Hammett ? values.No evidence could be found that electron transfer plays an important role in the epoxidation mechanism.The mechanistic possibilities are briefly discussed.Studies of the photoepoxidation reaction in a variety of solvents have also shown that the reaction is very insensitive to solvent effects.

Electrochemical oxidation-induced benzyl C–H carbonylation for the synthesis of aromatic α-diketones

Electrochemical oxidation-induced direct carbonylation of benzyl C–H bond for the synthesis of aromatic α-diketones is described. In this process, tetrabutylammonium iodide (nBu4NI) not only acts as an electrolyte, but its iodine anion is oxidized to an iodine radical at the anode, acting as a hydrogen atom transfer agent. The iodine radical extracts the benzyl hydrogen atom and causes the carbonylation of the benzyl position, where O2 in the air is used as an oxygen source.

Aerobic oxygenation of α-methylene ketones under visible-light catalysed by a CeNi3complex with a macrocyclic tris(salen)-ligand

A hetero-tetranuclear CeNi3 complex with a macrocyclic ligand catalysed the aerobic oxygenation of a methylene group adjacent to a carbonyl group under visible-light radiation to produce the corresponding α-diketones. The visible-light induced homolysis of the Ce-O bond of a bis(enolate) intermediate is proposed prior to aerobic oxygenation.

One-pot cascade synthesis of α-diketones from aldehydes and ketones in water by using a bifunctional iron nanocomposite catalyst

A new methodology for the synthesis of α-diketones was reportedviaa one-pot cascade process from aldehydes and ketones catalyzed by a bifunctional iron nanocomposite using H2O2as a green oxidant in water. The one-pot strategy showed excellent catalytic stability, comprehensive suitability of substrates and important practical utility for directly synthesizing biologically active and medicinally valuable N-heterocyclesviaan intermittent process.