ethyl 5-[[4-[2-[benzyl-[(2R)-2-(6-chloro-3-pyridyl)-2-hydroxyethyl]amino]ethyl]phenyl]sulfonyl]-2-(benzyloxy)benzoate

Base Information

Chemical Name:ethyl 5-[[4-[2-[benzyl-[(2R)-2-(6-chloro-3-pyridyl)-2-hydroxyethyl]amino]ethyl]phenyl]sulfonyl]-2-(benzyloxy)benzoate
CAS No.:870103-64-3
Molecular Formula:C₃₈H₃₇ClN₂O₆S
Molecular Weight:685.241
Hs Code.:

Synonyms:ethyl 5-[[4-[2-[benzyl-[(2R)-2-(6-chloro-3-pyridyl)-2-hydroxyethyl]amino]ethyl]phenyl]sulfonyl]-2-(benzyloxy)benzoate

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Chemical Property of ethyl 5-[[4-[2-[benzyl-[(2R)-2-(6-chloro-3-pyridyl)-2-hydroxyethyl]amino]ethyl]phenyl]sulfonyl]-2-(benzyloxy)benzoate

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Technology Process of ethyl 5-[[4-[2-[benzyl-[(2R)-2-(6-chloro-3-pyridyl)-2-hydroxyethyl]amino]ethyl]phenyl]sulfonyl]-2-(benzyloxy)benzoate

There total 1 articles about ethyl 5-[[4-[2-[benzyl-[(2R)-2-(6-chloro-3-pyridyl)-2-hydroxyethyl]amino]ethyl]phenyl]sulfonyl]-2-(benzyloxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 870103-32-5
5-[[4-[2-[benzyl[(2R)-2-(6-chloro-3-pyridyl)-2-hydroxyethyl]amino]ethyl]phenyl]sulfonyl]-2-(benzyloxy)benzoic acid

: 75-03-6
ethyl iodide

: 870103-64-3
ethyl 5-[[4-[2-[benzyl-[(2R)-2-(6-chloro-3-pyridyl)-2-hydroxyethyl]amino]ethyl]phenyl]sulfonyl]-2-(benzyloxy)benzoate

Guidance literature:: With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 3h;

Reference yield:

: 870103-64-3
ethyl 5-[[4-[2-[benzyl-[(2R)-2-(6-chloro-3-pyridyl)-2-hydroxyethyl]amino]ethyl]phenyl]sulfonyl]-2-(benzyloxy)benzoate

: 5158-46-3
methylzinc chloride

: 870103-65-4
ethyl 5-[[4-[2-[benzyl[(2R)-2-hydroxy-2-(6-methyl-3-pyridyl)ethyl]-amino]ethyl]phenyl]sulfonyl]-2-(benzyloxy)benzoate

Guidance literature:: ethyl 5-[[4-[2-[benzyl-[(2R)-2-(6-chloro-3-pyridyl)-2-hydroxyethyl]amino]ethyl]phenyl]sulfonyl]-2-(benzyloxy)benzoate; methylzinc chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 - 80 ℃; for 4h;

With edetate disodium; In tetrahydrofuran; water; ethyl acetate; for 0.333333h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 870103-64-3
ethyl 5-[[4-[2-[benzyl-[(2R)-2-(6-chloro-3-pyridyl)-2-hydroxyethyl]amino]ethyl]phenyl]sulfonyl]-2-(benzyloxy)benzoate

: 870103-72-3
5-[[4-[2-[benzyl-[(2R)-2-hydroxy-2-(6-methyl-3-pyridyl)ethyl]amino]-ethyl]phenyl]sulfonyl]-2-(benzyloxy)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 4 h / 20 - 80 °C

1.2: 0.33 h

2.1: sodium hydroxide / methanol; water / 6 h / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; water;