Technology Process of N-(4,5-bis(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl)-4-methoxybenzamide
There total 8 articles about N-(4,5-bis(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl)-4-methoxybenzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-amino-4,5-bis(4-methoxybenzyl)-1-methyl-1H-imidazole;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 0.5h;
Inert atmosphere;
4-methoxy-benzoyl chloride;
In
tetrahydrofuran; hexane;
at -78 - 25 ℃;
for 2h;
Inert atmosphere;
DOI:10.1016/j.ejmech.2014.06.016
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: triethylsilane; boron trifluoride diethyl etherate / tetrahydrofuran / 24 h / 0 - 60 °C / Inert atmosphere
2.1: ethylmagnesium bromide / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere
2.2: 12 h / 25 °C / Inert atmosphere
3.1: tetrahydrofuran / 12 h / 25 °C / Inert atmosphere
4.1: acetic acid; hydrogen; palladium 10% on activated carbon / methanol / 24 h / 50 °C / 30402 Torr
5.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 - 25 °C
5.2: 1 h / -78 - 25 °C
6.1: sodium tetrahydroborate / methanol / 12 h / 0 - 25 °C
7.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 - 20 °C / Inert atmosphere
7.2: 2 h / -78 - 25 °C / Inert atmosphere
With
triethylsilane; sodium tetrahydroborate; n-butyllithium; palladium 10% on activated carbon; boron trifluoride diethyl etherate; ethylmagnesium bromide; hydrogen; acetic acid;
In
tetrahydrofuran; methanol; hexane;
DOI:10.1016/j.ejmech.2014.06.016
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrahydrofuran / 12 h / 25 °C / Inert atmosphere
2.1: acetic acid; hydrogen; palladium 10% on activated carbon / methanol / 24 h / 50 °C / 30402 Torr
3.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 - 25 °C
3.2: 1 h / -78 - 25 °C
4.1: sodium tetrahydroborate / methanol / 12 h / 0 - 25 °C
5.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 - 20 °C / Inert atmosphere
5.2: 2 h / -78 - 25 °C / Inert atmosphere
With
sodium tetrahydroborate; n-butyllithium; palladium 10% on activated carbon; hydrogen; acetic acid;
In
tetrahydrofuran; methanol; hexane;
DOI:10.1016/j.ejmech.2014.06.016
