N³-Boc-3',5'-O-1,1,3,3-tetraisopropyl-1,3-disiloxane-2'-O-p-nitrophenylsulfonyl-5-methyluridine

Base Information

• Chemical Name: N³-Boc-3',5'-O-1,1,3,3-tetraisopropyl-1,3-disiloxane-2'-O-p-nitrophenylsulfonyl-5-methyluridine
• CAS No.: 1414853-71-6
• Molecular Formula: C₃₃H₅₁N₃O₁₃SSi₂
• Molecular Weight: 786.017

Synonyms:N³-Boc-3',5'-O-1,1,3,3-tetraisopropyl-1,3-disiloxane-2'-O-p-nitrophenylsulfonyl-5-methyluridine

Chemical Property of N³-Boc-3',5'-O-1,1,3,3-tetraisopropyl-1,3-disiloxane-2'-O-p-nitrophenylsulfonyl-5-methyluridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N³-Boc-3',5'-O-1,1,3,3-tetraisopropyl-1,3-disiloxane-2'-O-p-nitrophenylsulfonyl-5-methyluridine

There total 6 articles about N³-Boc-3',5'-O-1,1,3,3-tetraisopropyl-1,3-disiloxane-2'-O-p-nitrophenylsulfonyl-5-methyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C27H48N2O9Si2 (1266095-79-7) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → N3-Boc-3',5'-O-1,1,3,3-tetraisopropyl-1,3-disiloxane-2'-O-p-nitrophenylsulfonyl-5-methyluridine (1414853-71-6)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.tet.2012.10.001

Reference yield:

1-[(6aR,8R,9S,9aR)-tetrahydro-9-hydroxy-2,2,4,4-tetraisopropyl-6H-furo[3,2-f]-[1,3,5,2,4]trioxadisilocin-8-yl](5-methylpyrimidine)-2.4(1H.3H)-dione (130983-87-8) → N3-Boc-3',5'-O-1,1,3,3-tetraisopropyl-1,3-disiloxane-2'-O-p-nitrophenylsulfonyl-5-methyluridine (1414853-71-6)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0 °C

2: dmap

3: toluene-4-sulfonic acid / tetrahydrofuran

4: pyridine / dichloromethane / 12 h / 20 °C

With pyridine; dmap; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tet.2012.10.001

Reference yield:

5-Methyluridine (1463-10-1,642082-80-2) → N3-Boc-3',5'-O-1,1,3,3-tetraisopropyl-1,3-disiloxane-2'-O-p-nitrophenylsulfonyl-5-methyluridine (1414853-71-6)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine

2: triethylamine / dichloromethane / 0 °C

3: dmap

4: toluene-4-sulfonic acid / tetrahydrofuran

5: pyridine / dichloromethane / 12 h / 20 °C

With pyridine; dmap; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tet.2012.10.001

upstream raw materials:

C₂₇H₄₈N₂O₉Si₂

4-Nitrobenzenesulfonyl chloride

1-[(6aR,8R,9S,9aR)-tetrahydro-9-hydroxy-2,2,4,4-tetraisopropyl-6H-furo[3,2-f]-[1,3,5,2,4]trioxadisilocin-8-yl](5-methylpyrimidine)-2.4(1H_.3H)-dione

5-Methyluridine

Downstream raw materials:

N³-Boc-2'-O-p-nitrophenylsulfonyl-5-methyluridine

N³-Boc-3',5'-O-bis-tetrahydropyranyl-2'-O-p-nitrophenylsulfonyl-5-methyluridine

N³-Boc-3',5'-O-bis-methoxymethyl-2'-O-p-nitrophenylsulfonyl-5-methyluridine

N³-Boc-3',5'-O-bis-benzoyl-2'-O-p-nitrophenylsulfonyl-5-methyluridine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1414853-71-6 N³-Boc-3',5'-O-1,1,3,3-tetraisopropyl-1,3-disiloxane-2'-O-p-nitrophenylsulfonyl-5-methyluridine

Send

Send

Metric Ton KG G Pound L ML

Send

Send