(1R,2S)-2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenylethanol

Base Information

• Chemical Name: (1R,2S)-2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenylethanol
• CAS No.: 866457-04-7
• Molecular Formula: C₁₉H₂₄O₃
• Molecular Weight: 300.398
• Mol file: 866457-04-7.mol

Synonyms:(1R,2S)-2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenylethanol

Chemical Property of (1R,2S)-2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenylethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S)-2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenylethanol

There total 5 articles about (1R,2S)-2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran (866456-96-4) → (1R,2S)-2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenylethanol (866457-04-7)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; dichloromethane; at 20 ℃;

DOI:10.1016/j.tetasy.2005.06.033

Reference yield:

[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropane-1-ol (866456-94-2) → (1R,2S)-2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenylethanol (866457-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / hexamethylphosphoric acid triamide; dimethylformamide / 1 h / 20 °C

1.2: 84 percent / dimethylformamide; hexamethylphosphoric acid triamide / 20 °C

2.1: 0.171 g / p-TsOH / methanol; CH₂Cl₂ / 20 °C

With sodium hydride; toluene-4-sulfonic acid; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetasy.2005.06.033

Reference yield:

[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropionic acid 1,1-dimethylethyl ester (866456-92-0) → (1R,2S)-2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenylethanol (866457-04-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 94 percent / LiAlH₄ / diethyl ether / 1 h / 20 °C

2.1: NaH / hexamethylphosphoric acid triamide; dimethylformamide / 1 h / 20 °C

2.2: 84 percent / dimethylformamide; hexamethylphosphoric acid triamide / 20 °C

3.1: 0.171 g / p-TsOH / methanol; CH₂Cl₂ / 20 °C

With lithium aluminium tetrahydride; sodium hydride; toluene-4-sulfonic acid; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetasy.2005.06.033

upstream raw materials:

[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropane-1-ol

methanesulfonic acid [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropyl ester

[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-methylpropionic acid 1,1-dimethylethyl ester

Downstream raw materials:

oxophenylacetic acid [1R,2S]-2-(2-methoxy-1,1-dimethylethoxy)-1,2-diphenylethyl ester