di-t-butyl N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-L-glutamate

Base Information

Chemical Name:di-t-butyl N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-L-glutamate
CAS No.:127117-58-2
Molecular Formula:C₃₂H₃₉N₅O₆
Molecular Weight:589.692
Hs Code.:

Synonyms:di-t-butyl N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-L-glutamate

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Chemical Property of di-t-butyl N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-L-glutamate

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Technology Process of di-t-butyl N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-L-glutamate

There total 2 articles about di-t-butyl N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 77766-62-2
2-amino-6-(bromomethyl)-4-hydroxyquinazoline hydrobromide

: 112888-47-8
di-tert-butyl N-<4-(prop-2-ynylamino)benzoyl>-L-glutamate

: 127117-58-2
di-t-butyl N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-L-glutamate

Guidance literature:: With 2,4-dichlorophenoxyacetic acid dimethylamine; calcium carbonate; at 25 ℃; for 96h;
DOI:10.1002/jhet.5570260548

Reference yield:

: 76282-66-1
di-tert-butyl (S)-N-(p-aminobenzoyl)-glutamate

: 127117-58-2
di-t-butyl N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / toluene; ethanol / 3 h / Heating

2: 76 percent / DMA, CaCO₃ / 96 h / 25 °C

With 2,4-dichlorophenoxyacetic acid dimethylamine; potassium carbonate; calcium carbonate; In ethanol; toluene;
DOI:10.1002/jhet.5570260548