2-amino-6-(4-methoxyphenyl)pyrimidin-4-yl 4-methylbenzenesulfonate

Base Information

• Chemical Name: 2-amino-6-(4-methoxyphenyl)pyrimidin-4-yl 4-methylbenzenesulfonate
• CAS No.: 1000385-97-6
• Molecular Formula: C₁₈H₁₇N₃O₄S
• Molecular Weight: 371.417
• Mol file: 1000385-97-6.mol

Synonyms:2-amino-6-(4-methoxyphenyl)pyrimidin-4-yl 4-methylbenzenesulfonate

Chemical Property of 2-amino-6-(4-methoxyphenyl)pyrimidin-4-yl 4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amino-6-(4-methoxyphenyl)pyrimidin-4-yl 4-methylbenzenesulfonate

There total 2 articles about 2-amino-6-(4-methoxyphenyl)pyrimidin-4-yl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-amino-6-iodopyrimidin-4-yl 4-methylbenzenesulfonate (1000385-95-4) + 4-methoxyphenylboronic acid (5720-07-0) → 2-amino-6-(4-methoxyphenyl)pyrimidin-4-yl 4-methylbenzenesulfonate (1000385-97-6)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 100 ℃; for 0.416667h; microwave irradiation;

DOI:10.1016/j.tet.2007.07.100

Reference yield:

C11H10N3ClSO3 (1000385-94-3) + 4-methoxyphenylboronic acid (5720-07-0) → 2-amino-6-(4-methoxyphenyl)pyrimidin-4-yl 4-methylbenzenesulfonate (1000385-97-6) + 2-amino-4,6-bis(p-methoxyphenyl)pyrimidine (125968-55-0)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; microwave irradiation;

DOI:10.1016/j.tet.2007.07.100

Reference yield: 71.0%

2-amino-6-(4-methoxyphenyl)pyrimidin-4-yl 4-methylbenzenesulfonate (1000385-97-6) + phenylacetylene (536-74-3) → 4-(4-methoxyphenyl)-6-(phenylethynyl)pyrimidin-2-ylamine

Guidance literature:

With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; at 120 ℃; for 0.166667h; microwave irradiation;

DOI:10.1016/j.tet.2007.07.100

upstream raw materials:

2-amino-6-iodopyrimidin-4-yl 4-methylbenzenesulfonate

4-methoxyphenylboronic acid

C₁₁H₁₀N₃ClSO₃

Downstream raw materials:

4-(4-methoxyphenyl)-6-phenylpyrimidin-2-ylamine