4-(4-Methoxyphenyl)-6-phenylpyrimidin-2-amine

Base Information

• Chemical Name: 4-(4-Methoxyphenyl)-6-phenylpyrimidin-2-amine
• CAS No.: 59807-19-1
• Molecular Formula: C17H15N3O
• Molecular Weight: 277.326
• Hs Code.: 2933599090
• ChEMBL ID: CHEMBL4286323
• DSSTox Substance ID: DTXSID00485232
• Nikkaji Number: J2.451.737C
• Wikidata: Q82324229
• Mol file: 59807-19-1.mol

Synonyms:4-(4-methoxyphenyl)-6-phenylpyrimidin-2-amine;59807-19-1;CHEMBL4286323;DTXSID00485232;MFCD00725984;AKOS001873054;CCG-155170;SB58711;CS-0366353;N10422;4- (4-Methoxyphenyl)-6-phenyl-2-pyrimidinamin;4-(4-methoxyphenyl)-6-phenyl-pyrimidin-2-amine;A848232;4-(4-Methoxyphenyl)-6-phenylpyrimidin-2(1H)-imine;4-(4-METHOXYPHENYL)-6-PHENYL-2-PYRIMIDINYLAMINE

Chemical Property of 4-(4-Methoxyphenyl)-6-phenylpyrimidin-2-amine

Chemical Property:

• PSA: 61.76000
• LogP: 3.33150
• Storage Temp.: 2-8°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 277.121512110
• Heavy Atom Count: 21
• Complexity: 311

Purity/Quality:

97% ^*data from raw suppliers

4-(4-Methoxyphenyl)-6-phenylpyrimidin-2-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=NC(=NC(=C2)C3=CC=CC=C3)N

Technology Process of 4-(4-Methoxyphenyl)-6-phenylpyrimidin-2-amine

There total 23 articles about 4-(4-Methoxyphenyl)-6-phenylpyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

guanidine nitrate (113-00-8) + 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one (959-33-1) → 4-(4-methoxyphenyl)-6-phenylpyrimidin-2-ylamine (59807-19-1)

Guidance literature:

With titanium(IV) oxide; In ethanol; for 0.333333h; Time; UV-irradiation;

DOI:10.1016/j.jphotochem.2020.112648

Reference yield: 96.0%

C19H16N2O2 + guanidine hydrochloride (50-01-1) → 4-(4-methoxyphenyl)-6-phenylpyrimidin-2-ylamine (59807-19-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 12h;

DOI:10.1039/d1ra04319f

Reference yield: 93.0%

2-amino-6-phenylpyrimidin-4-yl 4-methylbenzenesulfonate (1000385-96-5) + 4-methoxyphenylboronic acid (5720-07-0) → 4-(4-methoxyphenyl)-6-phenylpyrimidin-2-ylamine (59807-19-1)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 120 ℃; for 0.25h; microwave irradiation;

DOI:10.1016/j.tet.2007.07.100

upstream raw materials:

trans-4-methoxychalcone

guanidine nitrate

trans-4'-methoxychalcone

guanidine hydrochloride

Downstream raw materials:

2-acetamido-6-(p-methoxyphenyl)-4-phenylpyrimidine

N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-N'-(4'-(p-methoxyphenyl)-6'-diphenylpyrimidin-2'-yl)thiourea

C₁₉H₁₆ClN₃O₂

3-[4'-(4''-methoxyphenyl)-6'-phenylpyrimidin-2'-yl]-2-phenylthiazolidin-4-one