3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)-nitrobenzene

Base Information

Chemical Name:3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)-nitrobenzene
CAS No.:1214265-35-6
Molecular Formula:C₁₄H₁₄F₂N₂O₄
Molecular Weight:312.273
Hs Code.:

Synonyms:3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)-nitrobenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)-nitrobenzene

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Technology Process of 3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)-nitrobenzene

There total 1 articles about 3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 129321-60-4
5,8-dioxa-10-azadispiro[2.0.44.33]undecane

: 66684-58-0
3,4,5-trifluoronitrobenzene

: 1214265-35-6
3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)-nitrobenzene

Guidance literature:: In acetonitrile; Reflux;

Reference yield:

: 1214265-35-6
3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)-nitrobenzene

: 1214265-36-7
C₁₄H₁₆F₂N₂O₂

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 2h; under 2068.65 Torr;

Reference yield:

: 1214265-35-6
3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)-nitrobenzene

: 1214265-37-8
N-carbobenzyloxy-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]aniline

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 2 h / 2068.65 Torr

2: sodium hydrogencarbonate / water; acetone / 20 °C / Ice bath

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; water; acetone;