ethyl (2Z)-3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}-2-propenoate

Base Information

Chemical Name:ethyl (2Z)-3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}-2-propenoate
CAS No.:1285514-52-4
Molecular Formula:C₂₄H₂₂N₂O₄
Molecular Weight:402.45
Hs Code.:

Synonyms:ethyl (2Z)-3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}-2-propenoate

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Chemical Property of ethyl (2Z)-3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}-2-propenoate

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Technology Process of ethyl (2Z)-3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}-2-propenoate

There total 5 articles about ethyl (2Z)-3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 1285514-50-2
5-formyl-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

: 1285514-52-4
ethyl (2Z)-3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}-2-propenoate

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 0.25h;

5-formyl-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield:

: 462-08-8
pyridin-3-ylamine

: 1285514-52-4
ethyl (2Z)-3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}-2-propenoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 72 h

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C

2.2: -78 - 20 °C

With potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 616-76-2
2-hydroxy-5-formylbenzoic acid

: 1285514-52-4
ethyl (2Z)-3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}-2-propenoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 24 h

2.1: water; lithium hydroxide / tetrahydrofuran; methanol

2.2: pH 1

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 72 h

4.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C

4.2: -78 - 20 °C

With water; potassium hexamethylsilazane; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;