2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(piperazin-1-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

Base Information

Chemical Name:2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(piperazin-1-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide
CAS No.:1616245-46-5
Molecular Formula:C₂₆H₂₃F₂N₉O
Molecular Weight:515.525
Hs Code.:

Synonyms:2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(piperazin-1-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

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Chemical Property of 2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(piperazin-1-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

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Technology Process of 2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(piperazin-1-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

There total 12 articles about 2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(piperazin-1-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1616234-39-9
tert-butyl 4-(4-(2-(2-fluoroisonicotinamido)imidazo[1,2-b]pyridazin-6-yl)-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)piperazine-1-carboxylate

: 1616245-46-5
2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(piperazin-1-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

: 1616235-36-9
tert-butyl 4-(1-methylhydrazinecarbonothioyl)piperazine-1-carboxylate

: 1616245-46-5
2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(piperazin-1-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol / 0 - 20 °C

1.2: 80 °C

2.1: dmap / dichloromethane / 0.5 h / 20 °C

3.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

4.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 100 °C / Inert atmosphere

5.1: hydrogenchloride; methanol / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 20 °C

With hydrogenchloride; methanol; dmap; potassium phosphate; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 1616245-46-5
2-fluoro-N-(6-(3-(4-fluorophenyl)-1-methyl-5-(piperazin-1-yl)-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol / 0 - 20 °C

1.2: 80 °C

2.1: dmap / dichloromethane / 0.5 h / 20 °C

3.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

4.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 100 °C / Inert atmosphere

5.1: hydrogenchloride; methanol / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 20 °C

With hydrogenchloride; methanol; dmap; potassium phosphate; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;