tert-butyl 4-(4-(2-(2-fluoroisonicotinamido)imidazo[1,2-b]pyridazin-6-yl)-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(2-(2-fluoroisonicotinamido)imidazo[1,2-b]pyridazin-6-yl)-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)piperazine-1-carboxylate
CAS No.:1616234-39-9
Molecular Formula:C₃₁H₃₁F₂N₉O₃
Molecular Weight:615.642
Hs Code.:

Synonyms:tert-butyl 4-(4-(2-(2-fluoroisonicotinamido)imidazo[1,2-b]pyridazin-6-yl)-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(2-(2-fluoroisonicotinamido)imidazo[1,2-b]pyridazin-6-yl)-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(2-(2-fluoroisonicotinamido)imidazo[1,2-b]pyridazin-6-yl)-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)piperazine-1-carboxylate

There total 12 articles about tert-butyl 4-(4-(2-(2-fluoroisonicotinamido)imidazo[1,2-b]pyridazin-6-yl)-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.4%

: 402-65-3
2-fluoropyridine-4-carboxylic acid

: 1616235-48-3
tert-butyl 4-(4-(2-aminoimidazo[1,2-b]pyridazin-6-yl)-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)piperazine-1-carboxylate

: 1616234-39-9
tert-butyl 4-(4-(2-(2-fluoroisonicotinamido)imidazo[1,2-b]pyridazin-6-yl)-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)piperazine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1616235-36-9
tert-butyl 4-(1-methylhydrazinecarbonothioyl)piperazine-1-carboxylate

: 1616234-39-9
tert-butyl 4-(4-(2-(2-fluoroisonicotinamido)imidazo[1,2-b]pyridazin-6-yl)-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethanol / 0 - 20 °C

1.2: 80 °C

2.1: dmap / dichloromethane / 0.5 h / 20 °C

3.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

4.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 100 °C / Inert atmosphere

5.1: hydrogenchloride; methanol / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; methanol; dmap; potassium phosphate; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 1616234-39-9
tert-butyl 4-(4-(2-(2-fluoroisonicotinamido)imidazo[1,2-b]pyridazin-6-yl)-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethanol / 0 - 20 °C

1.2: 80 °C

2.1: dmap / dichloromethane / 0.5 h / 20 °C

3.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

4.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 100 °C / Inert atmosphere

5.1: hydrogenchloride; methanol / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; methanol; dmap; potassium phosphate; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;