(3R,4S,4'S,5'S) N-(p-anisyl)-3-phenoxy-4-azetidin-2-one

Base Information

Chemical Name:(3R,4S,4'S,5'S) N-(p-anisyl)-3-phenoxy-4-azetidin-2-one
CAS No.:148903-77-9
Molecular Formula:C₃₂H₃₆N₂O₆
Molecular Weight:544.648
Hs Code.:

(3R,4S,4'S,5'S) N-(p-anisyl)-3-phenoxy-4-<N-t-butoxycarbonyl-2',2'-dimethyl-5'-phenyl-1',3'-oxazolidin-4'-yl>azetidin-2-one

Synonyms:(3R,4S,4'S,5'S) N-(p-anisyl)-3-phenoxy-4-azetidin-2-one

Suppliers and Price of (3R,4S,4'S,5'S) N-(p-anisyl)-3-phenoxy-4-azetidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S,4'S,5'S) N-(p-anisyl)-3-phenoxy-4-azetidin-2-one

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Technology Process of (3R,4S,4'S,5'S) N-(p-anisyl)-3-phenoxy-4-azetidin-2-one

There total 7 articles about (3R,4S,4'S,5'S) N-(p-anisyl)-3-phenoxy-4-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 701-99-5
Phenoxyacetyl chloride

: (4S,5S)-4-{[(E)-4-Methoxy-phenylimino]-methyl}-2,2-dimethyl-5-phenyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 148903-77-9
(3R,4S,4'S,5'S) N-(p-anisyl)-3-phenoxy-4-azetidin-2-one

Guidance literature:: With triethylamine; In dichloromethane; for 20h; Ambient temperature;
DOI:10.1016/S0957-4166(00)80160-3 DOI:10.1016/0040-4020(96)00463-2

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 148903-77-9
(3R,4S,4'S,5'S) N-(p-anisyl)-3-phenoxy-4-azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) Et₃N / 1.) toluene, reflux, 2.) CH₂Cl₂, 0 deg C, 4 h

2: 98 percent / DMSO, oxalyl chloride, Et₃N / CH₂Cl₂ / 2 h / -15 - 0 °C

3: anhyd. MgSO₄ / CH₂Cl₂ / 24 h / Ambient temperature

4: 74 percent / Et₃N / CH₂Cl₂ / 20 h / Ambient temperature

With oxalyl dichloride; magnesium sulfate; dimethyl sulfoxide; triethylamine; In dichloromethane;
DOI:10.1016/0040-4020(96)00463-2

Reference yield:

: 28143-91-1
(1S,2S)-2-amino-1-phenyl-1,3-diol

: 148903-77-9
(3R,4S,4'S,5'S) N-(p-anisyl)-3-phenoxy-4-azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) Et₃N / 1.) toluene, reflux, 2.) CH₂Cl₂, 0 deg C, 4 h

2: 98 percent / DMSO, oxalyl chloride, Et₃N / CH₂Cl₂ / 2 h / -15 - 0 °C

3: anhyd. MgSO₄ / CH₂Cl₂ / 24 h / Ambient temperature

4: 74 percent / Et₃N / CH₂Cl₂ / 20 h / Ambient temperature

With oxalyl dichloride; magnesium sulfate; dimethyl sulfoxide; triethylamine; In dichloromethane;
DOI:10.1016/0040-4020(96)00463-2