2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-2-(trimethylsilyloxy)acetonitrile

Base Information

Chemical Name:2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-2-(trimethylsilyloxy)acetonitrile
CAS No.:1265402-37-6
Molecular Formula:C₂₂H₃₀N₄OSi
Molecular Weight:394.592
Hs Code.:

Synonyms:2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-2-(trimethylsilyloxy)acetonitrile

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Chemical Property of 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-2-(trimethylsilyloxy)acetonitrile

Chemical Property:

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Technology Process of 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-2-(trimethylsilyloxy)acetonitrile

There total 6 articles about 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-2-(trimethylsilyloxy)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 1265402-31-0
4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidine-5-carbaldehyde

: 1265402-37-6
2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-2-(trimethylsilyloxy)acetonitrile

Guidance literature:: With zinc(II) iodide; In dichloromethane; at 0 - 20 ℃; for 1.5h;

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

: 1265402-37-6
2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-2-(trimethylsilyloxy)acetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron trifluoride diethyl etherate / copper(l) chloride; acetic acid / tetrahydrofuran / 21 h / Reflux

2.1: nitric acid / water / 0 - 20 °C

2.2: pH 8 / Cooling with ice

3.1: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / 1,4-dioxane / 96 h / 20 °C

4.1: diisobutylaluminium hydride / dichloromethane / 3 h / -78 - 0 °C / Inert atmosphere

4.2: 1 h

5.1: dipyridinium dichromate / dichloromethane / 21 h / 20 °C / Molecular sieve

6.1: zinc(II) iodide / dichloromethane / 1.5 h / 0 - 20 °C

With dipyridinium dichromate; boron trifluoride diethyl etherate; nitric acid; diisobutylaluminium hydride; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; zinc(II) iodide; acetic acid; copper(l) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 299949-24-9
ethyl 6-methyl-2-oxo-4-p-tolyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 1265402-37-6
2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-2-(trimethylsilyloxy)acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: nitric acid / water / 0 - 20 °C

1.2: pH 8 / Cooling with ice

2.1: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / 1,4-dioxane / 96 h / 20 °C

3.1: diisobutylaluminium hydride / dichloromethane / 3 h / -78 - 0 °C / Inert atmosphere

3.2: 1 h

4.1: dipyridinium dichromate / dichloromethane / 21 h / 20 °C / Molecular sieve

5.1: zinc(II) iodide / dichloromethane / 1.5 h / 0 - 20 °C

With dipyridinium dichromate; nitric acid; diisobutylaluminium hydride; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; zinc(II) iodide; In 1,4-dioxane; dichloromethane; water;