methyl 2-hydroxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate

Base Information

Chemical Name:methyl 2-hydroxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate
CAS No.:1265402-43-4
Molecular Formula:C₂₀H₂₅N₃O₃
Molecular Weight:355.437
Hs Code.:

Synonyms:methyl 2-hydroxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate

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Chemical Property of methyl 2-hydroxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate

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Technology Process of methyl 2-hydroxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate

There total 7 articles about methyl 2-hydroxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 67-56-1
methanol

: 1265402-37-6
2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-2-(trimethylsilyloxy)acetonitrile

: 1265402-43-4
methyl 2-hydroxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate

Guidance literature:: With sulfuric acid; at 0 - 20 ℃; for 24h; Reflux;

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

: 1265402-43-4
methyl 2-hydroxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: boron trifluoride diethyl etherate / copper(l) chloride; acetic acid / tetrahydrofuran / 21 h / Reflux

2.1: nitric acid / water / 0 - 20 °C

2.2: pH 8 / Cooling with ice

3.1: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / 1,4-dioxane / 96 h / 20 °C

4.1: diisobutylaluminium hydride / dichloromethane / 3 h / -78 - 0 °C / Inert atmosphere

4.2: 1 h

5.1: dipyridinium dichromate / dichloromethane / 21 h / 20 °C / Molecular sieve

6.1: zinc(II) iodide / dichloromethane / 1.5 h / 0 - 20 °C

7.1: sulfuric acid / 24 h / 0 - 20 °C / Reflux

With dipyridinium dichromate; sulfuric acid; boron trifluoride diethyl etherate; nitric acid; diisobutylaluminium hydride; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; zinc(II) iodide; acetic acid; copper(l) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 299949-24-9
ethyl 6-methyl-2-oxo-4-p-tolyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 1265402-43-4
methyl 2-hydroxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: nitric acid / water / 0 - 20 °C

1.2: pH 8 / Cooling with ice

2.1: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / 1,4-dioxane / 96 h / 20 °C

3.1: diisobutylaluminium hydride / dichloromethane / 3 h / -78 - 0 °C / Inert atmosphere

3.2: 1 h

4.1: dipyridinium dichromate / dichloromethane / 21 h / 20 °C / Molecular sieve

5.1: zinc(II) iodide / dichloromethane / 1.5 h / 0 - 20 °C

6.1: sulfuric acid / 24 h / 0 - 20 °C / Reflux

With dipyridinium dichromate; sulfuric acid; nitric acid; diisobutylaluminium hydride; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; zinc(II) iodide; In 1,4-dioxane; dichloromethane; water;