methyl 4-hydroxy-3-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)pyrazole-5-carboxylate

Base Information

• Chemical Name: methyl 4-hydroxy-3-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)pyrazole-5-carboxylate
• CAS No.: 90524-85-9
• Molecular Formula: C₃₂H₃₂N₂O₇
• Molecular Weight: 556.615

Synonyms:methyl 4-hydroxy-3-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)pyrazole-5-carboxylate

Chemical Property of methyl 4-hydroxy-3-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)pyrazole-5-carboxylate

Chemical Property:

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Technology Process of methyl 4-hydroxy-3-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)pyrazole-5-carboxylate

There total 8 articles about methyl 4-hydroxy-3-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

methanol (67-56-1) + ethyl 4-hydroxy-3-(2′,3′-O-isopropylidene-5′-O-trityl-β-D-ribofuranosyl)pyrazole-5-carboxylate (83686-32-2) → 4-hydroxy-3-(2′,3′-O-isopropylidene-5′-O-trityl-β-D-ribofuranosyl)pyrazole-5-carboxamide (83686-33-3) + methyl 4-hydroxy-3-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)pyrazole-5-carboxylate (90524-85-9)

Guidance literature:

With ammonia; at 90 - 95 ℃; for 3h;

Reference yield: 34.03%

2-Diazo-4-((3aS,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3-oxo-butyric acid methyl ester → methyl 4-hydroxy-3-(2',3'-O-isopropylidene-5'-O-trityl-α-D-ribofuranosyl)pyrazole-5-carboxylate (83694-49-9) + methyl 4-hydroxy-3-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)pyrazole-5-carboxylate (90524-85-9)

Guidance literature:

With sodium hydride; In diethyl ether; 1) RT, 4 h, 2) reflux, 30 min;

DOI:10.1016/S0008-6215(00)90705-5

Reference yield:

methyl 4-hydroxy-3-(2',3'-O-isopropylidene-5'-O-trityl-α-D-ribofuranosyl)pyrazole-5-carboxylate (83694-49-9) → methyl 4-hydroxy-3-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)pyrazole-5-carboxylate (90524-85-9)

Guidance literature:

With sodium methylate; In methanol; for 24h; Ambient temperature;

DOI:10.1016/S0008-6215(00)90705-5

upstream raw materials:

methanol

ethyl 4-hydroxy-3-(2′,3′-O-isopropylidene-5′-O-trityl-β-D-ribofuranosyl)pyrazole-5-carboxylate

methyl 4-hydroxy-3-(2',3'-O-isopropylidene-5'-O-trityl-α-D-ribofuranosyl)pyrazole-5-carboxylate

methyl 2-diazo-4-(2,3-O-isopropylidene-5-O-trityl-α-D-ribofuranosyl)-3-oxobutanoate

Downstream raw materials:

4-hydroxy-3-(2′,3′-O-isopropylidene-5′-O-trityl-β-D-ribofuranosyl)pyrazole-5-carboxamide

pyrazofurin

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