4-Amino-N-(4-benzo[d]isoxazol-3-ylmethyl-morpholin-2-ylmethyl)-5-chloro-2-methoxy-benzamide

Base Information

Chemical Name:4-Amino-N-(4-benzo[d]isoxazol-3-ylmethyl-morpholin-2-ylmethyl)-5-chloro-2-methoxy-benzamide
CAS No.:112886-77-8
Molecular Formula:C₂₁H₂₃ClN₄O₄
Molecular Weight:430.891
Hs Code.:

Synonyms:4-Amino-N-(4-benzo[d]isoxazol-3-ylmethyl-morpholin-2-ylmethyl)-5-chloro-2-methoxy-benzamide

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Chemical Property of 4-Amino-N-(4-benzo[d]isoxazol-3-ylmethyl-morpholin-2-ylmethyl)-5-chloro-2-methoxy-benzamide

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Technology Process of 4-Amino-N-(4-benzo[d]isoxazol-3-ylmethyl-morpholin-2-ylmethyl)-5-chloro-2-methoxy-benzamide

There total 5 articles about 4-Amino-N-(4-benzo[d]isoxazol-3-ylmethyl-morpholin-2-ylmethyl)-5-chloro-2-methoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37924-85-9
3-bromomethyl-1,2-benzisoxazole

: 112886-77-8
4-Amino-N-(4-benzo[d]isoxazol-3-ylmethyl-morpholin-2-ylmethyl)-5-chloro-2-methoxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃, KI / butan-2-one / 17 h / Heating

2: 10percent HCl / 4 h / Heating

3: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With hydrogenchloride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; In dichloromethane; butanone;
DOI:10.1248/cpb.40.652

Reference yield:

: 112913-96-9
2-(N-acetylaminomethyl)-4-benzylmorpholine

: 112886-77-8
4-Amino-N-(4-benzo[d]isoxazol-3-ylmethyl-morpholin-2-ylmethyl)-5-chloro-2-methoxy-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10percent Pd/C / ethanol; acetic acid / 60 °C

2: K₂CO₃, KI / butan-2-one / 17 h / Heating

3: 10percent HCl / 4 h / Heating

4: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With hydrogenchloride; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid; butanone;
DOI:10.1248/cpb.40.652

Reference yield:

: 112913-95-8
2-(N-acetylaminomethyl)morpholine

: 112886-77-8
4-Amino-N-(4-benzo[d]isoxazol-3-ylmethyl-morpholin-2-ylmethyl)-5-chloro-2-methoxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃, KI / butan-2-one / 17 h / Heating

2: 10percent HCl / 4 h / Heating

3: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With hydrogenchloride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; In dichloromethane; butanone;
DOI:10.1248/cpb.40.652