2,6-di-tert-butyl-4-{1-[5-(1-hydroxy-1-methyl-ethyl)-1H-imidazole-2-sulfonyl]-piperidin-4-ylsulfanyl}-phenol

Base Information

Chemical Name:2,6-di-tert-butyl-4-{1-[5-(1-hydroxy-1-methyl-ethyl)-1H-imidazole-2-sulfonyl]-piperidin-4-ylsulfanyl}-phenol
CAS No.:1073186-80-7
Molecular Formula:C₂₅H₃₉N₃O₄S₂
Molecular Weight:509.734
Hs Code.:

Synonyms:2,6-di-tert-butyl-4-{1-[5-(1-hydroxy-1-methyl-ethyl)-1H-imidazole-2-sulfonyl]-piperidin-4-ylsulfanyl}-phenol

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Chemical Property of 2,6-di-tert-butyl-4-{1-[5-(1-hydroxy-1-methyl-ethyl)-1H-imidazole-2-sulfonyl]-piperidin-4-ylsulfanyl}-phenol

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Technology Process of 2,6-di-tert-butyl-4-{1-[5-(1-hydroxy-1-methyl-ethyl)-1H-imidazole-2-sulfonyl]-piperidin-4-ylsulfanyl}-phenol

There total 4 articles about 2,6-di-tert-butyl-4-{1-[5-(1-hydroxy-1-methyl-ethyl)-1H-imidazole-2-sulfonyl]-piperidin-4-ylsulfanyl}-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1073187-03-7
2-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-sulfonyl]-3H-imidazole-4-carboxylic acid ethyl ester

: 676-58-4
methylmagnesium chloride

: 1073186-80-7
2,6-di-tert-butyl-4-{1-[5-(1-hydroxy-1-methyl-ethyl)-1H-imidazole-2-sulfonyl]-piperidin-4-ylsulfanyl}-phenol

Guidance literature:: 2-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-sulfonyl]-3H-imidazole-4-carboxylic acid ethyl ester; methylmagnesium chloride; In tetrahydrofuran; at 0 - 20 ℃; for 5h;

With sodium dihydrogenphosphate; water; In tetrahydrofuran;

Reference yield:

: 141699-59-4
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

: 1073186-80-7
2,6-di-tert-butyl-4-{1-[5-(1-hydroxy-1-methyl-ethyl)-1H-imidazole-2-sulfonyl]-piperidin-4-ylsulfanyl}-phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 60 °C

2.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

3.1: triethylamine / dichloromethane / 0.05 h

3.2: 2 h

4.1: tetrahydrofuran / 5 h / 0 - 20 °C

With hydrogenchloride; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1073186-96-5
2,6-di-tert-butyl-4-(piperidin-4-ylsulfanyl)-phenol hydrochloride

: 1073186-80-7
2,6-di-tert-butyl-4-{1-[5-(1-hydroxy-1-methyl-ethyl)-1H-imidazole-2-sulfonyl]-piperidin-4-ylsulfanyl}-phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.05 h

1.2: 2 h

2.1: tetrahydrofuran / 5 h / 0 - 20 °C

With triethylamine; In tetrahydrofuran; dichloromethane;