3-(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)propanoic acid

Base Information

Chemical Name:3-(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)propanoic acid
CAS No.:1332697-20-7
Molecular Formula:C₁₉H₁₆ClNO₃
Molecular Weight:341.794
Hs Code.:

Synonyms:3-(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)propanoic acid

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Chemical Property of 3-(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)propanoic acid

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Technology Process of 3-(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)propanoic acid

There total 11 articles about 3-(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1332697-21-8
diethyl 2-[(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)methyl]propane-1,3-dioate

: 1332697-20-7
3-(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)propanoic acid

Guidance literature:: With hydrogenchloride; water; acetic acid; at 120 ℃; for 2h;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: C₂₁H₁₉ClO₇

: 1332697-20-7
3-(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogenchloride; water; acetic acid / 3 h / 110 °C

2: methanol / 4 h / 20 °C

3: hydrogenchloride / ethyl acetate / 24 h / 20 °C

4: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

5: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 2 h / 0 °C

6: triethylamine / dichloromethane / 0.5 h / 20 °C

7: sodium hydride / tetrahydrofuran / 48 h / 0 - 20 °C

8: hydrogenchloride; water; acetic acid / 2 h / 120 °C

With hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; water; sodium hydride; acetic acid; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: C₁₇H₁₄ClNO₄

: 1332697-20-7
3-(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / ethyl acetate / 24 h / 20 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

3: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 2 h / 0 °C

4: triethylamine / dichloromethane / 0.5 h / 20 °C

5: sodium hydride / tetrahydrofuran / 48 h / 0 - 20 °C

6: hydrogenchloride; water; acetic acid / 2 h / 120 °C

With hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; water; sodium hydride; acetic acid; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2011.06.059