diethyl 2-[(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)methyl]propane-1,3-dioate

Base Information

Chemical Name:diethyl 2-[(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)methyl]propane-1,3-dioate
CAS No.:1332697-21-8
Molecular Formula:C₂₄H₂₄ClNO₅
Molecular Weight:441.911
Hs Code.:

Synonyms:diethyl 2-[(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)methyl]propane-1,3-dioate

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Chemical Property of diethyl 2-[(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)methyl]propane-1,3-dioate

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Technology Process of diethyl 2-[(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)methyl]propane-1,3-dioate

There total 10 articles about diethyl 2-[(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)methyl]propane-1,3-dioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: (6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)methyl methanesulfonate

: 105-53-3
diethyl malonate

: 1332697-21-8
diethyl 2-[(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)methyl]propane-1,3-dioate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 48h;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: C₂₁H₁₉ClO₇

: 1332697-21-8
diethyl 2-[(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)methyl]propane-1,3-dioate

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride; water; acetic acid / 3 h / 110 °C

2: methanol / 4 h / 20 °C

3: hydrogenchloride / ethyl acetate / 24 h / 20 °C

4: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

5: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 2 h / 0 °C

6: triethylamine / dichloromethane / 0.5 h / 20 °C

7: sodium hydride / tetrahydrofuran / 48 h / 0 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; water; sodium hydride; acetic acid; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: C₁₇H₁₄ClNO₄

: 1332697-21-8
diethyl 2-[(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)methyl]propane-1,3-dioate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / ethyl acetate / 24 h / 20 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

3: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 2 h / 0 °C

4: triethylamine / dichloromethane / 0.5 h / 20 °C

5: sodium hydride / tetrahydrofuran / 48 h / 0 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2011.06.059