LWTRFA

Base Information

• Chemical Name: LWTRFA
• CAS No.: 1566585-89-4
• Molecular Formula: C₃₉H₅₆N₁₀O₈
• Molecular Weight: 792.936
• Mol file: 1566585-89-4.mol

Synonyms:LWTRFA

Chemical Property of LWTRFA

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of LWTRFA

There total 2 articles about LWTRFA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

H-Ala-2-chlorotrityl resin + Fmoc-Leu-OH (35661-60-0) + N-Fmoc L-Phe (35661-40-6) + Fmoc-Thr(tBu)-OH (71989-35-0,138797-71-4) + 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester (143824-78-6,163619-04-3) + Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine (187618-60-6) → LWTRFA (1566585-89-4)

Guidance literature:

H-Ala-2-chlorotrityl resin; N-Fmoc L-Phe; With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; 2-chloro-trityl polystyrene Automated synthesizer;

With piperidine; In N,N-dimethyl-formamide; 2-chloro-trityl polystyrene Automated synthesizer;

Fmoc-Leu-OH; Fmoc-Thr(tBu)-OH; 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; Further stages;

DOI:10.1002/bip.22574

Reference yield: 63.0%

2-chlorotrityl-Ala-H polystyrene resin + Fmoc-Leu-OH (35661-60-0) + N-Fmoc L-Phe (35661-40-6) + Fmoc-Thr(tBu)-OH (71989-35-0,138797-71-4) + 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester (143824-78-6,163619-04-3) + Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine (187618-60-6) → LWTRFA (1566585-89-4)

Guidance literature:

2-chlorotrityl-Ala-H polystyrene resin; N-Fmoc L-Phe; With benzotriazol-1-ol; diisopropyl-carbodiimide; In water; N,N-dimethyl-formamide; at 20 ℃; for 1.33333h; 2-Chloro-Trityl-Ala-H polystyrene resin Inert atmosphere; Schlenk technique;

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.05h; 2-Chloro-Trityl-Ala-H polystyrene resin Inert atmosphere; Schlenk technique;

Fmoc-Leu-OH; Fmoc-Thr(tBu)-OH; 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; Further stages;

DOI:10.1021/ol403426u

upstream raw materials:

Fmoc-Leu-OH

N-Fmoc L-Phe

Fmoc-Thr(tBu)-OH

3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester