1,4-diamino-2-butyne

Base Information

Chemical Name:1,4-diamino-2-butyne
CAS No.:53878-96-9
Molecular Formula:C₄H₈N₂
Molecular Weight:84.1209
Hs Code.:2921290000
Mol file:53878-96-9.mol

Synonyms:1,4-Diamino-2-butyne;

Suppliers and Price of 1,4-diamino-2-butyne

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 10 raw suppliers

Chemical Property of 1,4-diamino-2-butyne

Chemical Property:

Vapor Pressure:0.374mmHg at 25°C
Melting Point:44°C
Refractive Index:1.513
Boiling Point:197.7 °C at 760 mmHg
Flash Point:84.3 °C
PSA：52.04000
Density:0.987 g/cm³
LogP:0.30780

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

General Description 1,4-Diamino-2-butyne is a versatile compound with notable chemical and physiological properties, serving as a key intermediate in the synthesis of unsymmetrical derivatives through efficient Cu(I)-catalyzed cross-coupling reactions. It can be derived from 1,4-dichloro-2-butyne and forms bis(amino acid) derivatives that adopt a C₂-symmetric turn conformation stabilized by intramolecular hydrogen bonds, as demonstrated by NMR studies. These structural features highlight its utility in designing conformationally constrained peptidomimetics and other bioactive molecules.

Technology Process of 1,4-diamino-2-butyne

There total 9 articles about 1,4-diamino-2-butyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 821-10-3
1,4-Dichloro-2-butyne

: 53878-96-9
but-2-yne-1,4-diamine

Guidance literature:: With ammonium hydroxide; at 40 ℃; for 3h;
DOI:10.1016/S0968-0896(03)00521-2

Reference yield: 36.0%

: 627-37-2
N-methyl-N-allylamine

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 142-84-7
di-n-propylamine

: 471-25-0
Propiolic acid

: 53878-96-9
but-2-yne-1,4-diamine

: N¹-allyl-N¹-methyl-N⁴,N⁴-dipropylbut-2-yne-1,4-diamine

Guidance literature:: N-methyl-N-allylamine; formaldehyd; In acetonitrile; at 20 ℃;

di-n-propylamine; Propiolic acid; With copper(l) iodide; In acetonitrile; at 80 ℃; for 0.5h; chemoselective reaction; Sealed tube; Microwave irradiation;
DOI:10.1021/acs.joc.1c00537

Reference yield: 30.0%

: 627-37-2
N-methyl-N-allylamine

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 111-92-2
dibutylamine

: 471-25-0
Propiolic acid

: 53878-96-9
but-2-yne-1,4-diamine

: N¹-allyl-N⁴,N⁴-dibutyl-N¹-methylbut-2-yne-1,4-diamine

Guidance literature:: N-methyl-N-allylamine; formaldehyd; In acetonitrile; at 20 ℃;

dibutylamine; Propiolic acid; With copper(l) iodide; In acetonitrile; at 80 ℃; for 0.5h; chemoselective reaction; Sealed tube; Microwave irradiation;
DOI:10.1021/acs.joc.1c00537