ethyl 1-(2,6-difluorophenyl)-6-hydroxy-1H-pyrazolo[3,4-b]pyrazine-5-carboxylate

Base Information

Chemical Name:ethyl 1-(2,6-difluorophenyl)-6-hydroxy-1H-pyrazolo[3,4-b]pyrazine-5-carboxylate
CAS No.:1188285-07-5
Molecular Formula:C₁₄H₁₀F₂N₄O₃
Molecular Weight:320.255
Hs Code.:

Synonyms:ethyl 1-(2,6-difluorophenyl)-6-hydroxy-1H-pyrazolo[3,4-b]pyrazine-5-carboxylate

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Chemical Property of ethyl 1-(2,6-difluorophenyl)-6-hydroxy-1H-pyrazolo[3,4-b]pyrazine-5-carboxylate

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Technology Process of ethyl 1-(2,6-difluorophenyl)-6-hydroxy-1H-pyrazolo[3,4-b]pyrazine-5-carboxylate

There total 3 articles about ethyl 1-(2,6-difluorophenyl)-6-hydroxy-1H-pyrazolo[3,4-b]pyrazine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1188285-06-4
1-(2,6-difluorophenyl)-4-nitroso-1H-pyrazol-5-amine

: 105-53-3
diethyl malonate

: 1188285-07-5
ethyl 1-(2,6-difluorophenyl)-6-hydroxy-1H-pyrazolo[3,4-b]pyrazine-5-carboxylate

Guidance literature:: diethyl malonate; With sodium ethanolate; In ethanol; at 20 ℃; for 0.0833333h;

1-(2,6-difluorophenyl)-4-nitroso-1H-pyrazol-5-amine; In ethanol; for 4h; Reflux;

With ammonium chloride; In water; ethyl acetate;

Reference yield:

: 1-(2,6-difluorophenyl)hydrazine hydrochloride

: 1188285-07-5
ethyl 1-(2,6-difluorophenyl)-6-hydroxy-1H-pyrazolo[3,4-b]pyrazine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / ethanol / 1.67 h / 20 °C / Reflux

2.1: hydrogenchloride / water / 10 h / Reflux

2.2: pH ~ 10 / Cooling with ice

3.1: hydrogenchloride; isopentyl nitrite / ethanol; ethyl acetate; isopropyl alcohol / 10 °C / Cooling with ice-NaCl

4.1: sodium ethanolate / ethanol / 0.08 h / 20 °C

4.2: 4 h / Reflux

With hydrogenchloride; sodium ethanolate; triethylamine; isopentyl nitrite; In ethanol; water; ethyl acetate; isopropyl alcohol;

Reference yield:

: 1188285-05-3
5-amino-1-(2,6-difluorophenyl)-1H-pyrazole-4-carbonitrile

: 1188285-07-5
ethyl 1-(2,6-difluorophenyl)-6-hydroxy-1H-pyrazolo[3,4-b]pyrazine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 10 h / Reflux

1.2: pH ~ 10 / Cooling with ice

2.1: hydrogenchloride; isopentyl nitrite / ethanol; ethyl acetate; isopropyl alcohol / 10 °C / Cooling with ice-NaCl

3.1: sodium ethanolate / ethanol / 0.08 h / 20 °C

3.2: 4 h / Reflux

With hydrogenchloride; sodium ethanolate; isopentyl nitrite; In ethanol; water; ethyl acetate; isopropyl alcohol;