4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)-N-methylaniline

Base Information

Chemical Name:4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)-N-methylaniline
CAS No.:1437281-26-9
Molecular Formula:C₂₃H₃₁N₃O₂Si
Molecular Weight:409.604
Hs Code.:

Synonyms:4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)-N-methylaniline

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Chemical Property of 4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)-N-methylaniline

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Technology Process of 4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)-N-methylaniline

There total 10 articles about 4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)-N-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.1%

: 1437281-25-8
4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)aniline

: 124-41-4
sodium methylate

: 1437281-26-9
4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)-N-methylaniline

Guidance literature:: 4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)aniline; sodium methylate; With formaldehyd; In methanol; at 0 - 75 ℃;

With sodium tetrahydroborate; In methanol; at 75 ℃; for 1h;

Reference yield:

: 1437281-24-7
7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-2-(4-nitrophenyl)-quinoxaline

: 1437281-26-9
4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)-N-methylaniline

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 0.5 h / 20 °C

2: sodium methylate / methanol / 4.5 h / 0 °C / Reflux

3: sodium tetrahydroborate / methanol / 1 h / Reflux

With sodium tetrahydroborate; palladium on activated charcoal; hydrogen; sodium methylate; In methanol; dichloromethane;
DOI:10.1021/ml4000707

Reference yield:

: 215656-99-8
4-{[tert-butyl(dimethyl)silyl]oxy}-2-nitroaniline

: 1437281-26-9
4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)-N-methylaniline

Guidance literature:: Multi-step reaction with 7 steps

1.1: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 7 h / 20 °C

2.1: dimethyl sulfoxide / 2 h / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

4.2: 80 °C

5.1: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 0.5 h / 20 °C

6.1: sodium methylate / methanol / 4.5 h / 0 °C / Reflux

7.1: sodium tetrahydroborate / methanol / 1 h / Reflux

With sodium tetrahydroborate; palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; sodium methylate; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ml4000707