Technology Process of 4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)-N-methylaniline
There total 10 articles about 4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)-N-methylaniline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)aniline; sodium methylate;
With
formaldehyd;
In
methanol;
at 0 - 75 ℃;
With
sodium tetrahydroborate;
In
methanol;
at 75 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 0.5 h / 20 °C
2: sodium methylate / methanol / 4.5 h / 0 °C / Reflux
3: sodium tetrahydroborate / methanol / 1 h / Reflux
With
sodium tetrahydroborate; palladium on activated charcoal; hydrogen; sodium methylate;
In
methanol; dichloromethane;
DOI:10.1021/ml4000707
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 7 h / 20 °C
2.1: dimethyl sulfoxide / 2 h / 20 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C
4.2: 80 °C
5.1: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 0.5 h / 20 °C
6.1: sodium methylate / methanol / 4.5 h / 0 °C / Reflux
7.1: sodium tetrahydroborate / methanol / 1 h / Reflux
With
sodium tetrahydroborate; palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; sodium methylate; potassium carbonate;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ml4000707
