Isoquinolin-6-ol

Base Information

• Chemical Name: Isoquinolin-6-ol
• CAS No.: 7651-82-3
• Molecular Formula: C9H7 N O
• Molecular Weight: 145.161
• Hs Code.: 2933499090
• Mol file: 7651-82-3.mol

Synonyms:6-Hydroxyisoquinoline

Chemical Property of Isoquinolin-6-ol

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 220ºC
• Boiling Point: 332.1 °C at 760 mmHg
• PKA: 9.15±0.10(Predicted)
• Flash Point: 154.6 °C
• PSA: 33.12000
• Density: 1.26 g/cm³
• LogP: 1.94040
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

6-Hydroxyisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Hydroxyisoquinoline is used in proteomics research such as in preparation of isoquinoline derivatives which act as protease inhibitors against trypsin. It was also used as a reagent in the study of a novel series of compounds that act as Wnt signaling pathway inhibitors and obtained by scaffold hybridization strategy from two known porcupine inhibitor classes.

Technology Process of Isoquinolin-6-ol

There total 7 articles about Isoquinolin-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methanol (67-56-1) + C18H15NO → isoquinolin-6-ol (7651-82-3) + (R)-1-phenyl-1-methoxyprop-2-ene (22665-13-0)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R)-(+)-(3,5-dioxa-4-phosphacyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-5H-dibenz[b,f]azepine; 3,5-dichlorobenzoic acid; at 25 ℃; for 10h; Inert atmosphere;

DOI:10.1038/s41557-020-0489-1

Reference yield: 82.0%

6-methoxyisoquinoline (52986-70-6) → isoquinolin-6-ol (7651-82-3)

Guidance literature:

With aqueous HBr; In water;

Reference yield: 75.0%

6-bromo-isoquinoline (34784-05-9) → isoquinolin-6-ol (7651-82-3)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium hydroxide; tert-butyl XPhos; In 1,4-dioxane; water; at 100 ℃; for 1.5h;

upstream raw materials:

6-methoxyisoquinoline

6-bromo-isoquinoline

methanol

Downstream raw materials:

(R)-(+)-tert-butyl 1-phenylprop-2-en-1-yl carbonate