Technology Process of methyl 6-(4-chloro-phenoxy)-2-propylnicotinate
There total 3 articles about methyl 6-(4-chloro-phenoxy)-2-propylnicotinate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 2-chloro-6-(4-chlorophenoxy)nicotinate; 1-propylmagnesium chloride;
Fe(acetylacetonate)3;
In
tetrahydrofuran; diethyl ether;
at -30 ℃;
for 1h;
With
water; ammonium chloride;
In
tetrahydrofuran; diethyl ether;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sulfuric acid / 8 - 14 h / 60 °C
1.2: 20 °C
2.1: triethylamine / N,N-dimethyl-formamide / 0.25 h / 20 - 22 °C
2.2: 4 - 5 h / 22 - 24 °C
2.3: 3 h / 20 - 25 °C
3.1: 1,2-bis(diphenylphosphino)ethane nickel(II) chloride / tetrahydrofuran; diethyl ether / 0.75 h / 25 - 28 °C
3.2: 0.25 h
With
1,2-bis(diphenylphosphino)ethane nickel(II) chloride; sulfuric acid; triethylamine;
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / N,N-dimethyl-formamide / 0.25 h / 20 - 22 °C
1.2: 4 - 5 h / 22 - 24 °C
1.3: 3 h / 20 - 25 °C
2.1: 1,2-bis(diphenylphosphino)ethane nickel(II) chloride / tetrahydrofuran; diethyl ether / 0.75 h / 25 - 28 °C
2.2: 0.25 h
With
1,2-bis(diphenylphosphino)ethane nickel(II) chloride; triethylamine;
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
