methyl 6-(4-chloro-phenoxy)-2-propylnicotinate

Base Information

Chemical Name:methyl 6-(4-chloro-phenoxy)-2-propylnicotinate
CAS No.:925207-28-9
Molecular Formula:C₁₆H₁₆ClNO₃
Molecular Weight:305.761
Hs Code.:

Synonyms:methyl 6-(4-chloro-phenoxy)-2-propylnicotinate

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Chemical Property of methyl 6-(4-chloro-phenoxy)-2-propylnicotinate

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Technology Process of methyl 6-(4-chloro-phenoxy)-2-propylnicotinate

There total 3 articles about methyl 6-(4-chloro-phenoxy)-2-propylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 906794-87-4
methyl 2-chloro-6-(4-chlorophenoxy)nicotinate

: 2234-82-4
1-propylmagnesium chloride

: 925207-28-9
methyl 6-(4-chloro-phenoxy)-2-propylnicotinate

Guidance literature:: methyl 2-chloro-6-(4-chlorophenoxy)nicotinate; 1-propylmagnesium chloride; Fe(acetylacetonate)3; In tetrahydrofuran; diethyl ether; at -30 ℃; for 1h;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether;

Reference yield:

: 38496-18-3
2,6-dichloropyridine-3-carboxylic acid

: 925207-28-9
methyl 6-(4-chloro-phenoxy)-2-propylnicotinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 8 - 14 h / 60 °C

1.2: 20 °C

2.1: triethylamine / N,N-dimethyl-formamide / 0.25 h / 20 - 22 °C

2.2: 4 - 5 h / 22 - 24 °C

2.3: 3 h / 20 - 25 °C

3.1: 1,2-bis(diphenylphosphino)ethane nickel(II) chloride / tetrahydrofuran; diethyl ether / 0.75 h / 25 - 28 °C

3.2: 0.25 h

With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; sulfuric acid; triethylamine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;

Reference yield:

: 65515-28-8
methyl 2,6-dichloronicotinate

: 925207-28-9
methyl 6-(4-chloro-phenoxy)-2-propylnicotinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / N,N-dimethyl-formamide / 0.25 h / 20 - 22 °C

1.2: 4 - 5 h / 22 - 24 °C

1.3: 3 h / 20 - 25 °C

2.1: 1,2-bis(diphenylphosphino)ethane nickel(II) chloride / tetrahydrofuran; diethyl ether / 0.75 h / 25 - 28 °C

2.2: 0.25 h

With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; triethylamine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;