N,N-bis<3-(4-fluorophenyl)-4-(methoxycarbonyl)-5-methyl-2,3-dihydrofuran-2-yl>hydroxylamine

Base Information

Chemical Name:N,N-bis<3-(4-fluorophenyl)-4-(methoxycarbonyl)-5-methyl-2,3-dihydrofuran-2-yl>hydroxylamine
CAS No.:124401-37-2
Molecular Formula:C₂₆H₂₅F₂NO₇
Molecular Weight:501.484
Hs Code.:

Synonyms:N,N-bis<3-(4-fluorophenyl)-4-(methoxycarbonyl)-5-methyl-2,3-dihydrofuran-2-yl>hydroxylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N-bis<3-(4-fluorophenyl)-4-(methoxycarbonyl)-5-methyl-2,3-dihydrofuran-2-yl>hydroxylamine

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Technology Process of N,N-bis<3-(4-fluorophenyl)-4-(methoxycarbonyl)-5-methyl-2,3-dihydrofuran-2-yl>hydroxylamine

There total 1 articles about N,N-bis<3-(4-fluorophenyl)-4-(methoxycarbonyl)-5-methyl-2,3-dihydrofuran-2-yl>hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5153-69-5,706-08-1
4-fluoro-β-nitrostyrene

: 105-45-3
acetoacetic acid methyl ester

: 124401-37-2
N,N-bis<3-(4-fluorophenyl)-4-(methoxycarbonyl)-5-methyl-2,3-dihydrofuran-2-yl>hydroxylamine

Guidance literature:: With sodium methylate; In methanol; at 0 ℃; for 2.25h;
DOI:10.1021/jm00163a011

Reference yield:

: 124401-37-2
N,N-bis<3-(4-fluorophenyl)-4-(methoxycarbonyl)-5-methyl-2,3-dihydrofuran-2-yl>hydroxylamine

: 6-{2-[4-(4-Fluoro-phenyl)-1-isopropyl-2-methyl-1H-pyrrol-3-yl]-ethyl}-4-hydroxy-tetrahydro-pyran-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 7.3 g / methanol / 1.) 40 deg C, 2 h, 2.) 50 deg C, 5 h

2: 1.) lithium aluminum hydride / diethyl ether / 1.) 0 deg C, 1 h, 2.) RT, 2 h

3: manganese dioxide, triethylamine / diethyl ether / 48 h / Ambient temperature

6: 1.) 1 M triethylborane, 2.) sodium borohydride / 1.) THF, 20 deg C, 140 min, 2.) -75 deg C, 12 h

7: H₂, triethylamine / 10percent Pd/C / methanol / 0.33 h / Ambient temperature

With manganese(IV) oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; triethyl borane; hydrogen; triethylamine; palladium on activated charcoal; In methanol; diethyl ether;
DOI:10.1021/jm00163a011

Reference yield:

: 124401-37-2
N,N-bis<3-(4-fluorophenyl)-4-(methoxycarbonyl)-5-methyl-2,3-dihydrofuran-2-yl>hydroxylamine

: 122223-38-5
methyl 3(RS),5(RS)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 7.3 g / methanol / 1.) 40 deg C, 2 h, 2.) 50 deg C, 5 h

2: 1.) lithium aluminum hydride / diethyl ether / 1.) 0 deg C, 1 h, 2.) RT, 2 h

3: manganese dioxide, triethylamine / diethyl ether / 48 h / Ambient temperature

6: 1.) 1 M triethylborane, 2.) sodium borohydride / 1.) THF, 20 deg C, 140 min, 2.) -75 deg C, 12 h

7: H₂, triethylamine / 10percent Pd/C / methanol / 0.33 h / Ambient temperature

With manganese(IV) oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; triethyl borane; hydrogen; triethylamine; palladium on activated charcoal; In methanol; diethyl ether;
DOI:10.1021/jm00163a011