Methyl 2-methyl-2-mesyloxymethyl-3-(4-chlorophenyl)-3-keto-propanoate

Base Information

Chemical Name:Methyl 2-methyl-2-mesyloxymethyl-3-(4-chlorophenyl)-3-keto-propanoate
CAS No.:131825-44-0
Molecular Formula:C₁₃H₁₅ClO₆S
Molecular Weight:334.778
Hs Code.:
DSSTox Substance ID:DTXSID701135348

Synonyms:131825-44-0;SCHEMBL10537981;KHEWWYQEJZOHIT-UHFFFAOYSA-N;DTXSID701135348;methyl 2-methyl-2-mesyloxymethyl-3-(4-chlorophenyl)-3-keto-propanoate;Methyl 4-chloro-I+/--methyl-I+/--[[(methylsulfonyl)oxy]methyl]-I(2)-oxobenzenepropanoate

Suppliers and Price of Methyl 2-methyl-2-mesyloxymethyl-3-(4-chlorophenyl)-3-keto-propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 2-methyl-2-mesyloxymethyl-3-(4-chlorophenyl)-3-keto-propanoate

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:334.0277871
Heavy Atom Count:21
Complexity:489

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(COS(=O)(=O)C)(C(=O)C1=CC=C(C=C1)Cl)C(=O)OC

Technology Process of Methyl 2-methyl-2-mesyloxymethyl-3-(4-chlorophenyl)-3-keto-propanoate

There total 4 articles about Methyl 2-methyl-2-mesyloxymethyl-3-(4-chlorophenyl)-3-keto-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.4%

: 124-63-0
methanesulfonyl chloride

: 131825-43-9
Methyl 2-(4-chlorobenzoyl)-2-(hydroxymethyl)propanoate

: 131825-44-0
Methyl 2-(4-chlorobenzoyl)-2-(mesyloxymethyl)propanoate

Guidance literature:: With triethylamine; In toluene; at 20 ℃; for 6h;
DOI:10.1002/ps.2780420406

Reference yield:

: methane sulfonyl chloride

: 131825-43-9
Methyl 2-(4-chlorobenzoyl)-2-(hydroxymethyl)propanoate

: 131825-44-0
Methyl 2-(4-chlorobenzoyl)-2-(mesyloxymethyl)propanoate

Guidance literature:: With triethylamine; In hexane; dichloromethane; water; ethyl acetate; toluene;

Reference yield:

: 6285-05-8
4'-chloropropiophenone

: 131825-44-0
Methyl 2-(4-chlorobenzoyl)-2-(mesyloxymethyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / NaH / tetrahydrofuran / Heating

2: pyridine; 'Triton'-B / methanol / 2 h / Heating

3: 43.4 percent / Et₃N / toluene / 6 h / 20 °C

With pyridine; N-benzyl-trimethylammonium hydroxide; sodium hydride; triethylamine; In tetrahydrofuran; methanol; toluene; 1: Substitution / 2: Formylation / 3: Substitution;
DOI:10.1002/ps.2780420406