Methyl 2-methyl-3-(4-chlorophenyl)-3-keto-propanoate

Base Information

Chemical Name:Methyl 2-methyl-3-(4-chlorophenyl)-3-keto-propanoate
CAS No.:63490-31-3
Molecular Formula:C₁₁H₁₁ClO₃
Molecular Weight:226.66
Hs Code.:
DSSTox Substance ID:DTXSID201242706
Nikkaji Number:J2.811.230K

Synonyms:63490-31-3;SCHEMBL10538105;LXBFKTZDEGGTIF-UHFFFAOYSA-N;DTXSID201242706;AKOS010952065;methyl 3-(4-chlorophenyl)-2-methyl-3-oxopropanoate;methyl 2-methyl-3-(4-chlorophenyl)-3-keto-propanoate;Methyl 4-chloro-I+/--methyl-I(2)-oxobenzenepropanoate

Suppliers and Price of Methyl 2-methyl-3-(4-chlorophenyl)-3-keto-propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Methyl 2-methyl-3-(4-chlorophenyl)-3-keto-propanoate

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:226.0396719
Heavy Atom Count:15
Complexity:244

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C(=O)C1=CC=C(C=C1)Cl)C(=O)OC

Technology Process of Methyl 2-methyl-3-(4-chlorophenyl)-3-keto-propanoate

There total 10 articles about Methyl 2-methyl-3-(4-chlorophenyl)-3-keto-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 34757-14-7
methyl 2-diazopropanoate

: 637-87-6
1-Chloro-4-iodobenzene

: 201230-82-2
carbon monoxide

: 63490-31-3
methyl 2-(4-chlorobenzoyl)-propionate

Guidance literature:: With triethylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In 1,2-dichloro-ethane; at 60 ℃; for 10h;
DOI:10.1002/anie.200906349

Reference yield: 74.0%

: 554-12-1
propanoic acid methyl ester

: 122-01-0
4-chloro-benzoyl chloride

: 63490-31-3
methyl 2-(4-chlorobenzoyl)-propionate

Guidance literature:: With 1-methyl-1H-imidazole; tributyl-amine; titanium tetrachloride; In dichloromethane; at -45 ℃; for 1h; Inert atmosphere;
DOI:10.1055/s-0035-1562482

Reference yield: 73.0%

: 614-45-9
tert-Butyl peroxybenzoate

: 22027-53-8
methyl 3-(4-chlorophenyl)-3-oxopropanoate

: 63490-31-3
methyl 2-(4-chlorobenzoyl)-propionate

Guidance literature:: With copper(II) bis(tetrafluoroborate); In water; chlorobenzene; at 100 ℃; for 2h; Inert atmosphere; Schlenk technique; Sealed tube;
DOI:10.1021/jo502204a