{4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid

Base Information

Chemical Name:{4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid
CAS No.:1315456-79-1
Molecular Formula:C₂₄H₂₁F₂N₃O₆
Molecular Weight:485.444
Hs Code.:

Synonyms:{4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid

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Chemical Property of {4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid

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Technology Process of {4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid

There total 10 articles about {4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1315456-78-0
{4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid tert-butyl ester

: 1315456-79-1
{4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 16h;

Reference yield:

: 1315456-69-9
2-(4-methoxy-3,5-dimethyl-benzoylamino)-malonic acid diethyl ester

: 1315456-79-1
{4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium methylate / methanol; ethanol / 3 h / 60 °C

2.1: sodium hydroxide / water; 1-methyl-pyrrolidin-2-one / 0.5 h / 0 °C

2.2: 2 h

3.1: trichlorophosphate / dichloromethane; tetrahydrofuran / 3 h / 60 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

5.1: boron tribromide / dichloromethane / 3 h / -20 - 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 20 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

9.1: trifluoroacetic acid / dichloromethane / 16 h

With sodium methylate; boron tribromide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1315456-72-4
N-(4,6-dihydroxy-2-methylsulfanyl-pyrimidin-5-yl)-4-methoxy-3,5-dimethyl-benzamide

: 1315456-79-1
{4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: trichlorophosphate / dichloromethane; tetrahydrofuran / 3 h / 60 °C

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

3: boron tribromide / dichloromethane / 3 h / -20 - 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

7: trifluoroacetic acid / dichloromethane / 16 h

With boron tribromide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;