{4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid tert-butyl ester

Base Information

Chemical Name:{4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid tert-butyl ester
CAS No.:1315456-78-0
Molecular Formula:C₂₈H₂₉F₂N₃O₆
Molecular Weight:541.552
Hs Code.:

Synonyms:{4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of {4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of {4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid tert-butyl ester

There total 10 articles about {4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2713-31-7
2,5-difluorophenol

: 1315456-77-9
[4-(5-methanesulfonyl-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethyl-phenoxy]-acetic acid tert-butyl ester

: 1315456-78-0
{4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid tert-butyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 1315456-69-9
2-(4-methoxy-3,5-dimethyl-benzoylamino)-malonic acid diethyl ester

: 1315456-78-0
{4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium methylate / methanol; ethanol / 3 h / 60 °C

2.1: sodium hydroxide / water; 1-methyl-pyrrolidin-2-one / 0.5 h / 0 °C

2.2: 2 h

3.1: trichlorophosphate / dichloromethane; tetrahydrofuran / 3 h / 60 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

5.1: boron tribromide / dichloromethane / 3 h / -20 - 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 20 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With sodium methylate; boron tribromide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1315456-72-4
N-(4,6-dihydroxy-2-methylsulfanyl-pyrimidin-5-yl)-4-methoxy-3,5-dimethyl-benzamide

: 1315456-78-0
{4-[5-(2,5-difluoro-phenoxy)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: trichlorophosphate / dichloromethane; tetrahydrofuran / 3 h / 60 °C

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

3: boron tribromide / dichloromethane / 3 h / -20 - 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With boron tribromide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;