2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(11-((2-(trimethylsilyl)ethoxy)methyl)-6,11-dihydropyrido[2',3':5,6]pyrano[4,3-b]-7-aza-indol-2-yl)benzofuran-3-carboxamide

Base Information

Chemical Name:2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(11-((2-(trimethylsilyl)ethoxy)methyl)-6,11-dihydropyrido[2',3':5,6]pyrano[4,3-b]-7-aza-indol-2-yl)benzofuran-3-carboxamide
CAS No.:1427034-56-7
Molecular Formula:C₃₇H₃₈FN₅O₆SSi
Molecular Weight:727.889
Hs Code.:

2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(11-((2-(trimethylsilyl)ethoxy)methyl)-6,11-dihydropyrido[2',3':5,6]pyrano[4,3-b]-7-aza-indol-2-yl)benzofuran-3-carboxamide

Synonyms:2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(11-((2-(trimethylsilyl)ethoxy)methyl)-6,11-dihydropyrido[2',3':5,6]pyrano[4,3-b]-7-aza-indol-2-yl)benzofuran-3-carboxamide

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Chemical Property of 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(11-((2-(trimethylsilyl)ethoxy)methyl)-6,11-dihydropyrido[2',3':5,6]pyrano[4,3-b]-7-aza-indol-2-yl)benzofuran-3-carboxamide

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Technology Process of 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(11-((2-(trimethylsilyl)ethoxy)methyl)-6,11-dihydropyrido[2',3':5,6]pyrano[4,3-b]-7-aza-indol-2-yl)benzofuran-3-carboxamide

There total 17 articles about 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(11-((2-(trimethylsilyl)ethoxy)methyl)-6,11-dihydropyrido[2',3':5,6]pyrano[4,3-b]-7-aza-indol-2-yl)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1333340-17-2
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

: 1427034-55-6
2-chloro-11-((2-(trimethylsilyl)ethoxy)methyl)-6,11-dihydropyrido[2',3':5,6]pyrano [4,3-b]-7-azaindole

: 1427034-56-7
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(11-((2-(trimethylsilyl)ethoxy)methyl)-6,11-dihydropyrido[2',3':5,6]pyrano[4,3-b]-7-aza-indol-2-yl)benzofuran-3-carboxamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate; XPhos; In 1,4-dioxane; water; at 100 ℃; for 4h; Inert atmosphere;

Reference yield:

: 271-63-6
7-Azaindole

: 1427034-56-7
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(11-((2-(trimethylsilyl)ethoxy)methyl)-6,11-dihydropyrido[2',3':5,6]pyrano[4,3-b]-7-aza-indol-2-yl)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere

1.2: 4 h / 0 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 2 h / -70 - -45 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate / 1,4-dioxane / 80 °C / Inert atmosphere

4.1: 1,4-dioxane; water / 3 h / 70 °C

5.1: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; potassium phosphate tribasic trihydrate; sodium hydride; XPhos; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 879132-46-4
1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine

: 1427034-56-7
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(11-((2-(trimethylsilyl)ethoxy)methyl)-6,11-dihydropyrido[2',3':5,6]pyrano[4,3-b]-7-aza-indol-2-yl)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 2 h / -70 - -45 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate / 1,4-dioxane / 80 °C / Inert atmosphere

3.1: 1,4-dioxane; water / 3 h / 70 °C

4.1: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; potassium phosphate tribasic trihydrate; XPhos; In tetrahydrofuran; 1,4-dioxane; water;